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Moumoujus

LUPEOL.

Valuable CAS 545-47-1 / SKIN CONDITIONING

Lupeol is a naturally occurring pentacyclic triterpenoid extracted from various plants. It is a potent ingredient recognized for its multifaceted skin benefits, primarily focusing on robust skin regeneration and protection. This active compound addresses concerns from compromised skin barriers to age-related degradation.

Summary

Skin conditioning Wound healing Anti-inflammatory Antioxidant Collagen synthesis stimulation Cell proliferation promotion Anti-aging

Science

Mechanism of Action

Lupeol actively promotes skin recovery and rejuvenation through several key pathways. It stimulates the migration of human epidermal keratinocytes and increases the contractile effect of human fibroblasts on collagen gels, both crucial steps for efficient wound closure and tissue repair. Its mechanism involves activating PI3K/Akt and p38 MAPK signaling while suppressing pro-inflammatory NF-κB pathways. Furthermore, Lupeol exhibits protective effects via MMP-2 and Tie-2 modulation, alongside its known anti-inflammatory, antioxidant, and cell proliferation-stimulating properties. It also enhances the production of high-quality type I collagen by inducing HSP47 and protects proteins from oxidative damage by scavenging free radicals.

Research

Clinical Evidence

High confidence
Effective range 0.0003–10%
Optimal

0.1%

Key findings

  1. 01 Significantly increased wound closure rate in human epidermal keratinocytes by 59% in vitro.
  2. 02 Demonstrated an 89% increase in wound reduction rate in rats after 14 days of topical application.
  3. 03 Significantly enhanced the contractile effect of human fibroblasts on collagen gels in vitro.

Transparency

Dusting Analysis

Not commonly dusted

Lupeol is proposed for use in cosmetic compositions across a broad range from 0.0003% to 10% by weight. Its demonstrated efficacy at low concentrations and significant biological activity indicate its role as an active ingredient, not merely a minor component or filler.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Due to its high lipophilicity and limited water solubility, Lupeol's bioavailability can be enhanced through chemical modifications like esterification or by encapsulating it in advanced delivery systems such as Solid Lipid Nanoparticles (SLN) or PLGA nanoparticles. It integrates well into oily solutions, emulsions (oil-in-water or water-in-oil), and various anhydrous or colloidal cosmetic bases.

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
10%
Sensitization risk Low

As a natural triterpenoid found in edible plants, Lupeol generally exhibits a favorable safety profile. Studies on its derivatives confirm low cytotoxicity and a stimulating effect on human cell proliferation, suggesting a low irritancy potential for topical applications. Low toxicity has been consistently reported for lupeol esters, supporting its use in cosmetic formulations.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Lupeol is a valuable triterpenoid for precision skincare, demonstrating robust clinical evidence for accelerating wound healing, stimulating high-quality collagen production, and offering significant anti-inflammatory and antioxidant protection across various skin types with a low irritancy potential.

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