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LUFFA CYLINDRICA LEAF EXTRACT.

Valuable CAS - / SKIN CONDITIONING

Luffa Cylindrica Leaf Extract is a multi-functional botanical ingredient recognized for its comprehensive skin benefits. Rich in flavonoids, it delivers potent antioxidant and anti-inflammatory actions, making it ideal for soothing irritated and sensitive skin. It also offers antimicrobial properties, contributing to overall skin health and protection.

Summary

Antioxidant Anti-inflammatory Skin conditioning Antimicrobial Moisturizer

Science

Mechanism of Action

The extract functions through several key pathways. Its antioxidant capacity stems from flavonoids like luteolin and apigenin, which effectively neutralize free radicals and provide a degree of photoprotection against environmental stressors. Anti-inflammatory effects are achieved by inhibiting inflammatory mediators such as PGE2 and histamine, and by reducing the production of chemokines like TARC and RANTES, thereby calming skin irritation and supporting conditions like atopic dermatitis. Furthermore, phytochemicals including tannins, saponins, phenolics, alkaloids, and flavonoids confer antimicrobial and antifungal activities, helping to manage various skin infections. The extract also supports skin hydration and conditioning, promoting a healthy skin barrier.

Research

Clinical Evidence

Medium confidence
Effective range 0.005% (in vitro) to 10 mg/mouse/day (topical in vivo)–50% (in vitro)%
Optimal

N/A

Key findings

  1. 01 In vitro, 0.01% ethanol and ethyl acetate extracts demonstrated average antioxidant properties with 53.31% and 54.73% inhibition respectively.
  2. 02 Various leaf extracts (n-hexane, chloroform, ethyl acetate) showed antioxidant activity with IC50 values between 50.32-61.24 µg/mL in a DPPH assay.
  3. 03 At 0.005%, the extract inhibited TARC and RANTES (AD-related chemokines) production in HaCaT cells by 20% and 12% respectively.
  4. 04 Topical application of 10 mg/mouse/day suppressed plasma IgE and histamine levels by 36% and 41% in sensitized mice, leading to reduced atopic dermatitis-like skin lesions.
  5. 05 Ethanol and ethyl acetate extracts (1.5625%-50%) exhibited moderate antibacterial activity against *Staphylococcus aureus*, *Salmonella typhi*, and *Bacillus subtilis*.
  6. 06 A crude ethyl acetate extract demonstrated in vivo antifungal activity in laboratory animals, promoting healing of infected skin.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

The specific compounds extracted, and thus the extract's properties, are influenced by the solvent polarity, with phenolic compounds favoring water and flavonoids more concentrated in ethanol extracts.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Oral safety studies in rats indicate low toxicity, with a methanolic leaf extract being safe up to 2g/kg orally, and an aqueous-methanol extract having an oral LD50 greater than 5000 mg/kg. Dermal toxicity for the leaf extract has not been determined. It is listed as a cosmetic ingredient for skin conditioning, with usage levels recommended up to 'not for fragrance use'.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Luffa Cylindrica Leaf Extract is a valuable multi-functional ingredient offering significant antioxidant, anti-inflammatory, and antimicrobial benefits, suitable for a wide range of skin types and conditions.

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