Science
Mechanism of Action
Lithospermum Officinale Extract exerts its effects through a spectrum of bioactive phytochemicals, such as phenolic compounds and flavonoids, which contribute to its significant antioxidant and antimicrobial activities. Its anti-inflammatory action helps to calm irritated skin and foster regeneration. Essential fatty acids like γ-linolenic acid (GLA) and stearidonic acid (SDA) are present, supporting the integrity of the skin's barrier function and maintaining optimal hydration levels. Research on the related species, Lithospermum erythrorhizon, further indicates its ability to improve the skin barrier by reducing trans-epidermal water loss (TEWL), mitigate oxidative stress, offer protection against UVB-induced photoaging, and help restore the skin's natural balance. Moreover, it has shown potential to suppress sebum production and minimize glycation, contributing to a clearer and more youthful complexion.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 In an in vitro study, Lithospermum officinale extract exhibited significantly higher anti-inflammatory effects on LPS-stimulated microglial cells compared to a commercial formulation.
- 02 Typical use levels for Lithospermum erythrorhizon root extract (a related species with similar active compounds) in cosmetics for improving skin barrier function and providing soothing effects.
- 03 Patch tests indicated that up to 10% of red pigment from Lithospermum erythrorhizon was acceptable from a skin irritation standpoint.
- 04 Topical compositions with Lithospermum erythrorhizon extract (as a 2% CO2 custom extraction product in 88% diisobutyl adipate and 10% tocopherol) were effective for suppressing sebum production and minimizing glycation in skin.
- 05 An emulsion containing Lithospermum erythrorhizon root extract (LES5.00) showed a maximum increase in skin humidity of 11.77 +/- 1.18% in healthy Asian females after 28 days of twice-daily application.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The natural color of Lithospermum officinale extract may impart a slight tint to cosmetic formulations. For the related Lithospermum erythrorhizon extract, its shikonin compounds have an innate tendency to polymerize and can undergo color changes with pH titration, which may impede solubility and skin penetration. Optimal stability in topical compositions is suggested within a pH range of approximately 4.0 to 8.0.
Synergies
- Lipophilic solubilizers (e.g., diisobutyl adipate)
- Free radical stabilizers (e.g., lipophilic antioxidants like tocopherol)
Conflicts
- pH extremes can trigger color change and polymerization of shikonin compounds (observed in related species), potentially impacting efficacy and stability.
Safety
Safety Profile
Lithospermum Officinale extract is generally considered safe for cosmetic use, with the EWG Skin Deep database rating it with 'LOW' concerns for cancer, allergies & immunotoxicity, developmental and reproductive toxicity, and use restrictions. However, some species of Lithospermum, including L. officinale, contain pyrrolizidine alkaloids which are toxic if ingested, though reported dermal absorption rates are poor. While serious side effects are rare, sensitivity testing is prudent, especially for highly reactive skin, as some individuals may experience allergic reactions to plant extracts. Patch tests for up to 10% of red pigment from Lithospermum erythrorhizon showed acceptable skin irritation levels. There is no specific SCCS opinion or formal FDA approval status for cosmetic use.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Lithospermum Officinale Extract is a valuable botanical offering broad benefits including anti-inflammatory, soothing, barrier-strengthening, and sebum-regulating properties, making it suitable for diverse skin types and concerns, despite some efficacy data relying on a related species.
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