Science
Mechanism of Action
LIQUIDAMBAR STYRACIFLUA FRUIT EXTRACT primarily functions as an antioxidant, attributed to its rich content of phenolic compounds and carbohydrates, effectively neutralizing free radicals via DPPH radical scavenging. While not exclusively from fruit extract, related research indicates potential anti-inflammatory action by inhibiting the hyaluronidase enzyme, and moderate antimicrobial activity. Historically, the resin from related Liquidambar species has been used for antiseptic purposes on skin.
Research
Clinical Evidence
Medium confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Components of Liquidambar Styraciflua Fruit Extract show versatility in solubility, with water-soluble pectic polysaccharides in aqueous extracts and other beneficial compounds extractable in ethanol. The precise optimal pH range for cosmetic formulation stability is currently undefined.
Safety
Safety Profile
LIQUIDAMBAR STYRACIFLUA FRUIT EXTRACT has not been reviewed for safety by the Cosmetic Ingredient Review (CIR) or the Scientific Committee on Consumer Safety (SCCS). Its usage is not reported in the FDA's Voluntary Cosmetics Reporting Program (VCRP). *In vitro* studies on cancer cell lines indicated high cytotoxicity for the ethanolic extract (S-EA) at 261.1 µg/mL (IC50, 24h) and 283.3 µg/mL (IC50, 48h) against MCF7 breast cancer cells, and approximately 25-50% cell viability reduction for the polysaccharide extract at 1000 µg/mL, though these are *in vitro* cancer cell findings and not directly indicative of skin irritation or safety in cosmetic applications for healthy skin.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While demonstrating promising *in vitro* antioxidant activity, the lack of comprehensive human clinical studies and official safety reviews necessitates further research for a definitive recommendation in precision skincare.
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References
Sources