Science
Mechanism of Action
This extract operates through several intricate pathways to benefit the skin. It acts as a potent antioxidant by effectively scavenging various free radicals, including DPPH, hydroxyl, and superoxide anion radicals, and by mitigating lipid peroxidation. Its anti-inflammatory action is demonstrated by reducing reactive oxygen species (ROS) formation, inhibiting pro-inflammatory cytokine secretion such as tumor necrosis factor α- and lipopolysaccharide-induced IL-6 and IL-12 p40, thereby preventing inflammatory responses. The extract also exhibits anti-allergic effects by inhibiting mast-cell-derived allergic inflammation. For skin brightening, it targets melanogenesis by inhibiting tyrosinase activity, downregulating MITF, and activating the ERK pathway. Furthermore, its anti-aging and anti-wrinkle benefits stem from its ability to suppress UVB-induced matrix metalloproteinase-1 (MMP-1) production, a key enzyme involved in collagen degradation.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 At a concentration of 1000µg/mL, the extract stimulated nitric oxide (NO) production in macrophage RAW264.7 cells.
- 02 Using a 50% ethanol twig extract (LTE), a concentration of 500µg/mL demonstrated antitumor activity against A549 (55.63%), HeLa (83.87%), and SNU719 (68.11%) cancer cells.
- 03 Various forms of the extract (LTE, LLE, LTW, LLW) significantly suppressed UVB-induced MMP-1 production in HS68 cells, with reductions ranging from 76.08% to 88.28%.
- 04 Compounds isolated from Lindera obtusiloba stem, at IC50 values between 1.8 and 24.1 µM, markedly suppressed LPS-triggered IL-6 and IL-12 p40 production in bone marrow-derived dendritic cells.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The extract demonstrates stability under processing conditions, commonly prepared using 50% ethanol at 70°C for several hours.
Safety
Safety Profile
While the Korean Food and Drug Administration (KFDA) has approved specific components (hyperin and isoquercitrin) found within Lindera obtusiloba extract, a comprehensive safety assessment for the extract itself for cosmetic use by major bodies like CIR, SCCS, or FDA is not yet explicitly available. Paula's Choice notes the ingredient as 'not rated' due to ongoing review, suggesting continuous evaluation of its safety profile.
Your Skin
Skin Compatibility
Our Assessment
Verdict
LINDERA OBTUSILOBA BRANCH EXTRACT is a valuable multi-functional ingredient, offering significant antioxidant, anti-inflammatory, anti-aging, and brightening benefits across all skin types, with a low potential for irritation.
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References
Sources