Science
Mechanism of Action
The extract contains secoiridoids and other active compounds that function as potent antioxidants, mitigating oxidative stress from environmental aggressors. Its anti-inflammatory action is evidenced by its ability to inhibit key inflammatory mediators, including nitric oxide (NO), prostaglandin E2, inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6), thereby soothing irritation and reducing visible redness. Furthermore, in vitro studies indicate a weak proliferative effect on human dermal papilla cells, suggesting a potential role in hair health.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 In vitro evaluations demonstrated inhibition of inflammatory markers like NO, prostaglandin E2, iNOS, and COX-2, as well as cytokines TNF-α and IL-6, at concentrations up to 500 μg/mL, indicating significant soothing potential.
- 02 Key secoiridoids (Oleuropein, 8Z-nüzhenide, GL-3) from Ligustrum japonicum exhibited weak proliferative activity on human dermal papilla cells, showing a 10-20% increase in proliferation compared to control in in vitro models.
Transparency
Dusting Analysis
No data available regarding common dusting practices or specific dusting thresholds for this ingredient in cosmetic formulations.
The Formula
Formulation
Safety
Safety Profile
LIGUSTRUM JAPONICUM FRUIT is registered in the FDA's Substance Registration System (UNII 4Z71G49H7S). However, its general use has not undergone comprehensive modern safety evaluation. Safety in specific populations, including young children, pregnant or nursing women, and individuals with severe liver or kidney disease, has not been established. No specific CIR or SCCS assessment is available for this extract.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This extract demonstrates valuable antioxidant and anti-inflammatory properties, with in vitro evidence supporting skin soothing, anti-aging benefits, and even potential hair health, though comprehensive safety data for specific populations is currently limited.
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References
Sources