Science
Mechanism of Action
Ligusticum Chuanxiong Root Extract performs its therapeutic actions through a complex of bioactive compounds, including ferulic acid, ligustilide, tetramethylpyrazine (TMP), and ligusticum CX polysaccharides (LCP). These constituents work synergistically to mitigate inflammatory responses, combat oxidative stress, and notably boost blood supply to the dermal layers. This improved circulation aids in achieving a more serene and hydrated complexion, alongside providing antiplatelet, endothelial cell protective, and anti-apoptotic benefits.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 The clinical efficacy of Ligusticum Chuanxiong Root Extract is intrinsically linked to its active metabolites. Ferulic acid, a pivotal compound, is mandated by the 2020 Chinese Pharmacopoeia to constitute at least 0.01% of the dried Ligusticum chuanxiong root, recognized for its anti-inflammatory effects and ability to enhance blood flow.
- 02 Ligustilide, another significant phthalide component, has been observed to reach concentrations of 1% within Szechwan lovage rhizome (SLR) and up to 58% in the volatile oil extracted from SLR, contributing substantially to the extract's overall pharmaceutical activities.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
This extract, particularly its primary phthalide compounds such as Z-ligustilide, demonstrates instability, being susceptible to oxidation and degradation by light. It necessitates storage in sealed containers, in cool and dark environments. Studies indicate Z-ligustilide purity decreases significantly at ambient temperatures, shows improved stability at 4°C, and is generally stable when stored at -20°C.
Safety
Safety Profile
While no specific CIR or SCCS assessments have been conducted, Ligusticum Chuanxiong Root Extract is acknowledged as an 'Approved Herbal Substance Name' by ICID. Its established safety for human intake in natural products and health supplements suggests a favorable safety profile for cosmetic applications.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Ligusticum Chuanxiong Root Extract is a valuable botanical renowned for its potent anti-inflammatory, antioxidant, and microcirculation-boosting capabilities, making it highly compatible with all skin types for targeted precision skincare formulations.
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