Science
Mechanism of Action
Ligularia stenocephala extract functions as a multi-target agent by actively inhibiting lipid peroxidation and superoxide anion formation, key indicators of oxidative stress. It efficiently scavenges DPPH radicals with an IC50 of 0.28 mg/mL and exhibits 96.67±0.09% ABTS radical scavenging activity (ethyl acetate fraction), alongside peroxynitrite-scavenging activity (IC50 of 1.62±0.03 µg/ml for the methanol extract). Furthermore, in vitro studies indicate robust anti-inflammatory action through the suppression of inflammatory mediators such as NF-κB, p-ERK, ERK, COX-2, c-Fos, and p-STAT, while concurrently promoting PPARγ expression in LPS-induced cells. The extract also possesses direct antimicrobial capabilities.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
A specific optimal pH range for stability in cosmetic formulations has not been established. High extraction yields observed with both water (60.35%) and organic solvents like n-butanol, n-hexane, and ethyl acetate suggest the presence of compounds with varying polarities, enhancing its versatility in diverse cosmetic bases.
Safety
Safety Profile
No specific safety assessments or reviews by regulatory bodies such as CIR, SCCS, or FDA were found for Ligularia stenocephala extract. Comprehensive safety data, particularly for topical application in humans, is currently lacking.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Ligularia stenocephala extract presents compelling in vitro antioxidant, anti-inflammatory, and antimicrobial benefits, but the absence of human clinical studies and formal safety assessments requires further investigation for its definitive role in precision skincare.
Related
Similar Ingredients
Finding similar ingredients…
References
Sources