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Moumoujus

LIGNOSUS RHINOCERUS SCLEROTIUM EXTRACT.

Valuable / ANTIOXIDANT

Lignosus Rhinocerus Sclerotium Extract, derived from the Tiger Milk Mushroom, is a multifaceted botanical active. Research indicates its potent antioxidant and anti-inflammatory capabilities, alongside benefits for collagen synthesis and melanin inhibition, positioning it as a promising ingredient for advanced skin health formulations.

Summary

Antioxidant Anti-inflammatory Collagen Booster Skin Brightening Cytoprotective Immunomodulatory

Science

Mechanism of Action

This extract operates through several key pathways beneficial for skin. It exhibits robust antioxidant properties by neutralizing free radicals and mitigating oxidative stress, attributed to its rich phenolic content. Its anti-inflammatory action involves reducing pro-inflammatory cytokines such as TNF-alpha, IL-1β, and IL-8, which are crucial mediators of skin inflammation. Furthermore, preliminary studies suggest its capacity to enhance collagen production and inhibit melanin formation, addressing concerns related to skin aging and hyperpigmentation.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 A protein component of the cold water extract demonstrated potent inhibition of TNF-alpha production in macrophage cells, indicating significant anti-inflammatory activity.
  2. 02 An aqueous extract displayed significant cytoprotective effects against hydrogen peroxide-induced oxidative stress in rat PC12 cells, safeguarding cellular integrity.
  3. 03 A mushroom sclerotial water extract inhibited melanin formation and enhanced human procollagen type 1 production, suggesting benefits for skin brightening and structural support.

Transparency

Dusting Analysis

Not commonly dusted

Current research data does not provide sufficient information to assess if this ingredient is commonly dusted or to establish specific dusting thresholds relevant for topical formulations.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Effective extraction of its bioactive compounds is observed with cold water, suggesting that some active principles may be sensitive to heat, which should be considered during formulation.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Preclinical toxicological evaluations in rats, involving oral administration up to 1000 mg/kg for 180 days, established a no-observed-adverse-effect level (NOAEL) above this concentration. Oral administration at 100 mg/kg did not affect fertility or induce teratogenic effects. The extract was non-genotoxic up to 5000 µg/plate in an Ames test. An in vitro study specifically noted no skin and eye irritation.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Lignosus Rhinocerus Sclerotium Extract is a valuable ingredient, demonstrating potent antioxidant and anti-inflammatory effects alongside promising collagen-boosting and melanin-inhibiting properties, warranting its inclusion in advanced skincare formulations despite limited human topical studies.

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