Science
Mechanism of Action
This extract functions as a potent antioxidant by effectively scavenging free radicals like DPPH and superoxide, while simultaneously boosting endogenous antioxidant enzymes such as GSH, SOD, and CAT. It counteracts skin aging by regulating gene expression impacted by UVB radiation, stimulating pro-collagen type I synthesis, and inhibiting collagen-degrading enzymes (MMP-1, collagenase, elastase). For hyperpigmentation, it reduces tyrosinase activity and modulates key melanin synthesis proteins (MITF, TRP1, TRP2). Furthermore, it strengthens the skin barrier by up-regulating tight junction proteins (Claudin-1, Occludin, ZO-1) and aids in skin repair by promoting epithelial tissue regeneration and collagen synthesis, also exhibiting antibacterial properties.
Research
Clinical Evidence
High confidence3%
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Aqueous and ethanol extracts are commonly utilized, indicating good solubility in these solvents. While an optimum pH of 6.0 was noted for extraction/stabilization in a synthetic medium, specific cosmetic formulation stability across pH ranges is not detailed. However, its incorporation into a cream base did not negatively impact stability or structural-mechanical properties in one study.
Safety
Safety Profile
Lespedeza cuneata Extract lacks specific review by CIR or SCCS for cosmetic use, and no specific FDA cosmetic status is available. General safety evaluations of an aqueous extract in animal studies (non-cosmetic context) at high doses (250 mg/Kg) showed no organ abnormalities or toxicity. In vitro studies confirm it is generally non-irritating to human dermal fibroblasts.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Lespedeza Cuneata Extract is a valuable ingredient, offering broad-spectrum benefits including advanced photoaging protection, significant skin brightening, and robust barrier support, making it ideal for precision skincare formulations.
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