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Moumoujus

LESPEDEZA BICOLOR BARK EXTRACT.

Insufficient Data / SKIN CONDITIONING

Lespedeza Bicolor Bark Extract is a botanical ingredient rich in flavonoids, tannins, and phenolic compounds. In vitro studies indicate its potential for significant antioxidant, anti-inflammatory, and depigmenting effects, contributing to overall skin health.

Summary

Anti-inflammatory Antioxidant Skin Brightening Antimicrobial Skin Conditioning Tissue Regeneration Support

Science

Mechanism of Action

This extract leverages its diverse phytochemical profile to modulate skin health. Its anti-inflammatory action is attributed to flavonoids like rutin and quercetin, alongside tannins and phenolic compounds, which inhibit LPS-induced nitric oxide production and suppress inflammatory markers such as COX-2 and TNF-α. Antioxidant properties stem from its ability to scavenge DPPH free radicals and reduce Fe3+. Furthermore, it demonstrates tyrosinase inhibitory effects for potential depigmentation, provides antimicrobial activity against various microorganisms, and phenolic compounds may support tissue regeneration, contributing to skin conditioning by maintaining soft, smooth, and hydrated skin.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 An ethyl acetate fraction of Lespedeza bicolor extract, at a concentration of 50 µg/mL in vitro, demonstrated anti-inflammatory, antioxidant, and tyrosinase inhibitory effects.
  2. 02 Robust radical scavenging activity was observed, with DPPH IC50 values ranging from 35.4 µg/mL to 87.3 ± 5.6 µg/mL, and an ABTS scavenging IC50 of 56.8 ± 3.2 µg/mL.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Low

Comprehensive oral, dermal, and inhalation toxicity assessments for Lespedeza Bicolor Bark Extract are currently undetermined. Regulatory bodies, including the Cosmetic Ingredient Review (CIR) and the Scientific Committee on Consumer Safety (SCCS), have not formally reviewed this ingredient. While EWG Skin Deep indicates low general concerns for cancer, allergies, and developmental/reproductive toxicity, it underscores the limited data availability for a full risk assessment.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While Lespedeza Bicolor Bark Extract demonstrates promising in vitro anti-inflammatory, antioxidant, and brightening properties, the current lack of human clinical trials and comprehensive safety assessments necessitates further research for a definitive verdict in precision skincare.

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