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Moumoujus

LEPTOSPERMUM SCOPARIUM LEAF EXTRACT.

Valuable CAS 223749-44-8 / SKIN CONDITIONING

Derived from the Manuka plant, Leptospermum Scoparium Leaf Extract is a multi-functional ingredient renowned for its potent antimicrobial, anti-inflammatory, and antioxidant properties. It targets key concerns such as acne, oxidative stress, and irritation, promoting a clearer and healthier complexion. Its broad-spectrum action makes it particularly beneficial for sensitive and oily skin types.

Summary

Antimicrobial/antibacterial Antioxidant Tonic

Science

Mechanism of Action

Leptospermum Scoparium Leaf Extract exerts its beneficial effects primarily through active compounds such as beta-triketones (including leptospermone, iso-leptospermone, and flavesone) and sesquiterpene hydrocarbons. These constituents are responsible for its strong antibacterial and antifungal actions, effectively combating microorganisms implicated in breakouts and infections. Additionally, it provides anti-inflammatory relief and acts as an antioxidant, mitigating oxidative stress. Evidence also suggests its capacity to block harmful UVB radiation, which contributes to preventing skin damage, collagen degradation, and signs of premature aging.

Research

Clinical Evidence

High confidence
Effective range 0.048–2%
Optimal

0.5%

Key findings

  1. 01 Manuka leaf oil extract is suggested for formulations to reduce inflammation, protect from oxidative stress, and provide antimicrobial benefits, suitable for acne-prone and sensitive skin.
  2. 02 Concentrations in this range can exhibit synergistic antibacterial activity and excellent biocompatibility. A 0.5% manuka oil coating demonstrated potential for preventing inflammation due to microbial infection.
  3. 03 A 10% manuka oil solution in DMSO effectively inhibited *Staphylococcus aureus*, *S. sobrinus*, and *S. mutans*, with a Minimum Inhibitory Concentration (MIC) of 0.048% (480 µg/mL).
  4. 04 Manuka oil demonstrated antibacterial activity against resistant Gram-negative bacteria, including *Pseudomonas aeruginosa*, *Escherichia coli*, *Klebsiella pneumoniae*, and *Proteus mirabilis*, with MIC values starting at ≥1% v/v and MBC values at ≥2%.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

This oil-soluble extract's composition can vary based on factors like climate, season, harvesting, and plant age. It requires storage in sealed containers under cool, dry conditions to maintain stability.

Conflicts

  • strong acids
  • strong oxidizing agents

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Generally considered non-hazardous, with oral toxicity tests showing it to be essentially non-toxic. Skin irritation tests yielded a Primarily Irritation Index (PII) of 0.0, classifying it as non-irritating and a non-sensitizer in human patch tests. However, Manuka Essential Oil, a component of the extract, may induce allergic skin reactions in sensitive individuals.

Your Skin

Skin Compatibility

No Normal
No Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Leptospermum Scoparium Leaf Extract is a valuable ingredient, particularly for acne-prone, oily, and sensitive skin, offering confirmed antimicrobial, anti-inflammatory, and antioxidant benefits across a clinically relevant dose range.

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