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LEPTOSPERMONE.

Insufficient Data CAS 567-75-9 / HAIR CONDITIONING, SKIN CONDITIONING

Leptospermone, a potent cyclic β-triketone isolated from Manuka oil, is recognized for its significant antimicrobial, antifungal, and antioxidant capacities. This active compound is typically utilized in targeted skincare formulations, particularly for conditions associated with microbial overgrowth, such as acne-prone skin, and for general skin conditioning.

Antimicrobial Antifungal Antioxidant

Science

As a cyclic β-triketone, Leptospermone exerts its primary effects by disrupting the cellular integrity and metabolic processes of various microorganisms, including bacteria and fungi, thereby inhibiting their proliferation on the skin surface. Furthermore, it possesses intrinsic antioxidant activity, contributing to the neutralization of reactive oxygen species and mitigation of oxidative stress.


Research

Low confidence
Effective range N/A
Optimal

N/A


Transparency

Not commonly dusted

The Formula

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Leptospermone exhibits low aqueous solubility, preferring oil-based environments. Its integration into essential oil compositions may contribute to chemical instability and high volatility. For optimal delivery and stability, oil-in-water emulsion systems are recommended for this hydrophobic compound.


Safety

CIR Status
Not reviewed
Sensitization risk Moderate

No specific CIR, SCCS, or FDA status is available for Leptospermone as a standalone cosmetic ingredient. A product-level safety assessment involving Leptospermone suggested it is unlikely to cause skin irritation or photo-toxic effects under normal use conditions. However, the presence of trace allergenic compounds within Leptospermone-containing essential oils necessitates careful consideration for individuals with existing sensitivities, as these may potentially trigger a reaction.


Your Skin

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Insufficient Data

Leptospermone demonstrates promising antimicrobial and antioxidant properties, yet comprehensive clinical efficacy and safety data as a standalone cosmetic ingredient are currently limited.


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