Science
Mechanism of Action
Its efficacy stems from high concentrations of naturally occurring antioxidants, phenolics, and flavonoids, which actively scavenge free radicals, thereby mitigating oxidative stress at a cellular level. Beyond its protective antioxidant action, the extract exhibits direct antimicrobial activity against various bacteria, contributing to a balanced skin microbiome. Additionally, preliminary studies suggest antiangiogenic effects, influencing vessel development and cellular processes potentially via MAPK/p38 signaling, aligning with the broader enhanced biological activity observed in fermented botanical extracts, including anti-inflammatory and skin-restorative benefits.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Strong antioxidant capacity demonstrated in vitro across various assays, with EC50 values ranging from 0.22–0.39 mg/mL (β-carotene bleaching method) to 0.63–0.48 mg/mL (reducing power methods) and 1.18–0.98 mg/mL (DPPH radical scavenging method).
- 02 An ethanolic extract exhibited significant antioxidant capacity (84.3% inhibition in a linoleic acid system) and potent in vitro antibacterial activity against various bacteria, including Micrococcus flavus, Staphylococcus aureus, and Escherichia coli.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
While optimal mycelial growth of L. nuda strains was observed at pH 7 during the fermentation process, specific stability data for the final extract within cosmetic formulations is currently unavailable.
Safety
Safety Profile
No specific CIR, SCCS, or FDA safety assessments for 'LEPISTA NUDA FERMENT EXTRACT' have been identified. A toxicological evaluation of Lepista nuda mycelium (not the fermented extract) in rats indicated no mutagenic effects or systemic toxicity at 3 g/kg body weight, suggesting a relatively benign profile for ingestion, but direct skin safety for cosmetic applications requires further study.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This fermented extract demonstrates potent antioxidant and antimicrobial activities in vitro, suggesting a valuable role in advanced skin protection and purification, though further human skin studies are warranted for comprehensive dermatological understanding.
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References
Sources