Science
Mechanism of Action
The multi-faceted action of this extract is primarily driven by Plukenetia Volubilis Seed Extract, which upregulates key anti-aging genes, including Connective Tissue Growth Factor (CTGF) and FOXO3. This mechanism significantly increases dermal density, leading to enhanced skin firmness and resilience, alongside a notable reduction in roughness, wrinkles, and facial sagginess. It also delivers essential skin-nourishing fatty acids and potent antioxidants, such as vitamin E, while supporting ceramide production for reinforced barrier function and protection against external stressors. Complementing this, Lepidium Meyenii (Maca) root extract actively stimulates skin cellular communication and nutrient absorption, bolstering protein synthesis and tissular adhesion to mitigate aging effects. It further contributes polysaccharides, amino acids, phenolics, and minerals, providing additional antioxidant and potential anti-inflammatory benefits.
Research
Clinical Evidence
Medium confidence5%
Key findings
- 01 Clinical evaluations of Hydrolyzed Plukenetia Volubilis Seed Extract (NaturePep® Sacha Inchi) demonstrated a significant 45% reduction in facial sagginess after 28 days of use.
- 02 Skin roughness parameters were decreased by over 20% across three different measures within 21 days of using Hydrolyzed Plukenetia Volubilis Seed Extract.
- 03 Studies confirm the effectiveness of Plukenetia Volubilis Seed Extract in promoting overall skin rejuvenation and anti-aging benefits, including improved skin firmness, resilience, and visible reduction of wrinkles and facial sagginess over 21 to 28 days.
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
The combined ingredient's safety profile has not been explicitly reviewed by CIR or SCCS. Plukenetia Volubilis Seed Oil is generally considered well-tolerated for topical use, non-toxic, and non-sensitizing, with typical cosmetic use levels ranging from 1-5%. However, the EWG Skin Deep database notes potential high contamination concerns and association with liver toxicity for 'Hydrolyzed Plukenetia Volubilis Seed Extract', based on broader safety assessments of the plant's various parts. Lepidium Meyenii (Maca) is generally considered safe with good human tolerance, primarily in the context of oral consumption.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This ingredient offers significant proven anti-aging and skin conditioning benefits through dermal restructuring and texture improvement, but its broader safety profile warrants further detailed assessment due to potential contamination concerns noted for a related extract.
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