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Moumoujus

LEPIDIUM MEYENII EXTRACT.

Valuable / SKIN CONDITIONING

Derived from the Peruvian maca root, Lepidium Meyenii Extract is a multi-functional botanical renowned for its adaptogenic properties. It works to revitalize skin by stimulating key cellular functions, enhancing structural integrity, and promoting an even, luminous complexion.

Summary

Antioxidant Moisturizer/Humectant Soothing Anti-aging Skin Brightening Improves Elasticity Reduces Redness Sebum Regulation Promotes Cell Renewal

Science

Mechanism of Action

Lepidium Meyenii Extract acts on the skin through multiple biological pathways. It stimulates human keratinocytes to significantly increase the synthesis of Collagen IV, a crucial component of the basal lamina, and integrin β1, vital for cell adhesion, thereby reinforcing skin structure and elasticity. It also promotes fibroblast synthesis, contributing to improved skin suppleness and anti-aging effects by reducing the appearance of wrinkles. The extract regulates pigment production through tyrosinase inhibition, leading to brighter skin and protection against UV-induced damage. Its potent antioxidant compounds, including macamides, neutralize free radicals that degrade collagen and elastin. Furthermore, it exhibits anti-inflammatory effects, soothing irritation and redness, supports skin's natural repair mechanisms, encourages cell renewal for a smoother texture, and can regulate sebum production, benefiting oily skin.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Observed a strong increase (up to 46%) in collagen IV synthesis and increased synthesis of integrin β1, a critical cell adhesion marker.
  2. 02 Non-fermented maca root extracts demonstrated dose-dependent tyrosinase inhibition (approximately 25% at 2.5%, 34% at 5%, and 47% at 10%). Fermented maca extracts dose-dependently inhibited melanin production and intracellular tyrosinase activity in B16F10 cells.
  3. 03 Maca peptide extract maintained normal cell viability.
  4. 04 Red maca extract reduced wound healing delays associated with inflammation at high altitudes in mice.

Transparency

Dusting Analysis

Not commonly dusted

Information regarding 'dusting' practices for this ingredient is not available in the provided research. Effective concentrations are noted in clinical studies, suggesting use at functional levels rather than trace amounts.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

The preparation method is crucial for optimal biological effects. While raw maca powder is largely water-insoluble, water-soluble peptide extracts can be obtained via enzymatic hydrolysis for cosmetic applications. Key active compounds, macamides, are lipid-soluble (non-polar).

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Lepidium Meyenii (Maca) generally exhibits a robust safety profile, with minimal adverse effects documented in preclinical and clinical studies. In vitro assessments indicate low toxicity, preserving cell viability at concentrations up to 10 mg/mL for methanolic/aqueous extracts. Topical safety is supported by SkinSAFE, which classifies it as 'Irritant Free,' 'Teen SAFE,' 'Lip SAFE,' 'Baby SAFE,' and 'Eyelid SAFE.' No specific CIR or SCCS assessment has been found.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Lepidium Meyenii Extract is a valuable, multi-faceted ingredient with demonstrated benefits for skin aging, brightening, and structural integrity, supported by preclinical evidence and an excellent safety profile for diverse skin types.

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