Science
Mechanism of Action
This extract derives its efficacy from bioactive compounds including diterpenes, triterpenes, flavonoids, and phenolic acids. On a cellular level, it suppresses oxidative stress by reducing intracellular reactive oxygen species (ROS) and inhibiting lipid peroxidation, while simultaneously upregulating key antioxidant enzymes like SOD2, CAT, and GPx. Its anti-inflammatory action involves inhibiting PGE2 production and decreasing pro-inflammatory cytokines such as TNF-alpha and IL-1beta. Furthermore, it supports DNA repair processes and demonstrates antibacterial activity against common skin bacteria like S. aureus and S. epidermidis.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 In HS68 cells, a methanol extract at concentrations from 0.025% to 0.8% significantly suppressed UVB-induced cytotoxicity, oxidative cell death, and the generation of intracellular reactive oxygen species, also inhibiting lipid peroxidation in a dose-dependent manner.
- 02 Plant extracts ranging from 0.005% to 0.05% demonstrated protective effects and stimulated DNA repair in Chinese hamster ovary (CHO) cells exposed to H2O2. Preincubation with 0.05% extract enhanced the expression of critical antioxidant genes (SOD2, CAT, and GPx).
- 03 Topical application of an ethanol extract (0.3-3 mg/ear) to mice ear tissue significantly reduced edema, myeloperoxidase activity, and levels of inflammatory mediators (TNF-α, IL-1β), while increasing ferric reducing/antioxidant power, confirming its antioxidant and anti-inflammatory properties.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Phytocosmetic formulations containing polyphenols, common in botanical extracts like Leonurus Sibiricus Seed Extract, are generally more stable within a slightly acidic pH range, ideally between 4.7 and 6.5. No specific optimal pH range was found for this extract, but typical skin-compatible pH values are recommended for formulation stability.
Safety
Safety Profile
No dedicated safety review by CIR or SCCS is available for Leonurus Sibiricus Seed Extract. General toxicity studies on the plant indicate high safety at standard doses, with adverse effects only noted at extremely high concentrations (5.0-25 g/kg body weight). EWG Skin Deep rates Leonurus Sibiricus Extract as 'Low' for concerns related to cancer, allergies, and developmental/reproductive toxicity.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Leonurus Sibiricus Seed Extract is a valuable botanical ingredient, providing robust antioxidant, anti-inflammatory, and protective benefits suitable for diverse skin types and precision skincare formulations.
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References
Sources