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Moumoujus

LEONURUS SIBIRICUS LEAF EXTRACT.

Valuable CAS - / SKIN CONDITIONING

Leonurus Sibiricus Leaf Extract, derived from the Siberian motherwort plant, is a botanical powerhouse recognized for its multifaceted benefits in skincare. It offers robust antioxidant and anti-inflammatory properties, alongside promoting enhanced wound healing. This extract is particularly suited for supporting skin recovery and mitigating environmental stressors.

Summary

Skin Conditioning Antioxidant Anti-inflammatory Wound Healing UVB Protection

Science

Mechanism of Action

This extract operates through several key pathways to enhance skin health. It significantly reduces intracellular Reactive Oxygen Species (ROS) and lipid peroxidation, which are critical markers of oxidative stress. By upregulating antioxidant genes such as SOD2, CAT, and GPx, it bolsters the skin's natural defense mechanisms. Furthermore, it exhibits potent anti-inflammatory action by inhibiting the NF-kB signaling pathway, thereby reducing the production of pro-inflammatory cytokines like TNF-α, IL-6, and IL-8. Its wound-healing capabilities stem from stimulating fibroblast proliferation, which is essential for collagen synthesis and ultimately contributes to more uniform tissue repair. The extract also demonstrates antibacterial activity against various bacteria, including S. aureus and S. epidermis, further supporting skin integrity.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

10% (m/v) in a gel formulation demonstrated better wound healing evolution in Wistar rats, leading to more homogeneous healing and improved visual appearance.

Transparency

Dusting Analysis

Not commonly dusted

No information regarding dusting or common adulteration practices for Leonurus Sibiricus Leaf Extract was found in the provided research.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Ethanolic extracts have shown stability in pH buffer solutions ranging from 7.8–8.0 for the quantification of specific compounds like leonurine. Water-soluble extractive values are also reported, suggesting good general stability for aqueous formulations.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

While generally considered safe at low doses, animal studies suggest that very high concentrations (e.g., 5.0 and 25 g/kg body weight) may induce harmful effects, whereas 0.5 g/kg body weight showed no toxic effects. Further safety data, particularly for topical human use at various concentrations, is needed, especially for high-dose applications.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Leonurus Sibiricus Leaf Extract is a valuable ingredient, particularly for sensitive, dry, and normal skin, offering robust antioxidant, anti-inflammatory, and wound-healing benefits with promising mechanistic support.

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