Science
Mechanism of Action
This extract functions by actively reducing intracellular reactive oxygen species (ROS) and stimulating DNA repair mechanisms, thereby safeguarding cells from oxidative stress. It enhances the expression of intrinsic antioxidant enzymes such as SOD2, CAT, and GPx. Furthermore, Leonurus Sibiricus Extract modulates inflammatory pathways by inhibiting pro-inflammatory mediators including PGE2, TNF-α, and IL-1β, while also curbing lipid peroxidation. Additional reported actions encompass antibacterial, wound healing, astringent, moisturizing, and skin tightening effects, potentially involving a reduction in MMP-9 expression.
Research
Clinical Evidence
Medium confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The extract is frequently prepared using aqueous methanol or ethanol, indicating its solubility in both water and alcohols. While a stable pH range of 7.8-8.0 was observed for a buffer solution in an analytical context, this does not directly define the optimal pH range for its stability within a cosmetic formulation.
Safety
Safety Profile
No specific safety assessments by CIR, SCCS, or FDA for Leonurus Sibiricus Extract in cosmetic applications have been identified. However, the Leonurus genus as a whole generally exhibits a high safety profile at standard dosages, with toxic reactions, such as liver and kidney issues, typically only manifesting at extremely elevated doses or under specific physiological conditions.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Leonurus Sibiricus Extract is a valuable botanical ingredient, demonstrating robust antioxidant, anti-inflammatory, and protective properties that make it highly beneficial for enhancing skin resilience and addressing multiple concerns in precision skincare formulations.
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References
Sources