Science
Mechanism of Action
This extract exerts its dermatological effects through several biological pathways. Its rich flavonoid composition delivers robust antioxidant protection by neutralizing oxidative stress. It possesses significant anti-inflammatory capabilities, notably by repressing Thymic stromal lymphopoietin (TSLP) expression at both mRNA and protein levels, and by modulating inflammasome components, critical in conditions like atopic dermatitis. Furthermore, Leonurus Japonicus Extract encourages the generation of natural moisturizing factors, enhancing skin hydration. For pigmentation, it inhibits melanin synthesis by downregulating melanocytic lineage-specific transcription factor (MITF) and melanogenic enzymes via the PI3K-Akt-mTOR and β-catenin pathways, while also reducing tyrosinase and matrix metalloproteinase (MMP-2, MMP-9) activities. Its anti-aging properties include stimulating collagenase synthesis and inhibiting hydrogen peroxide (H2O2) generation, contributing to wrinkle reduction and improved skin elasticity. Additionally, its polyphenolic compounds may support wound healing by modulating inflammation and promoting collagen synthesis.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Demonstrated a repression of TSLP expression (at mRNA and protein levels), alongside decreased SPINK5, PYCARD, IL-1β, and NOD2 gene expressions, indicating significant potential against atopic dermatitis.
- 02 Significantly reduced LPS-induced intracellular reactive oxygen species (ROS), showed cytoprotective effects, and exhibited anti-MMP-2, anti-MMP-9, and anti-tyrosinase activities. Polysaccharide extracts were more potent than α-arbutin and ursolic acid in inhibiting intracellular ROS and tyrosinase protein expression, suggesting strong anti-pigmentation benefits.
- 03 Displayed the highest antioxidant effect (via DPPH assay), significantly increased collagenase synthesis, and inhibited H2O2 generation in a dose-dependent manner, supporting its anti-aging properties.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
An optimal pH of 3.07 was identified for the concentration process of alkaloids from the extract; however, this value may not directly reflect the optimal pH range for stability within a finished cosmetic formulation.
Safety
Safety Profile
No specific safety assessments from CIR, SCCS, or FDA for skincare use were found. While general toxicity studies for the plant suggest a high safety profile at reasonable doses, with mild liver and kidney inflammatory lesions only at high short-term doses, the possibility of allergic reactions, including skin irritation or rashes, exists for sensitive individuals.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Leonurus Japonicus Extract is a valuable, versatile botanical ingredient demonstrating significant efficacy in addressing inflammation, oxidative stress, hyperpigmentation, and signs of aging across diverse skin types.
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