Science
Mechanism of Action
This extract's efficacy stems from a diverse profile of bioactive constituents, including leonurine, stachydrine, iridoid glycosides, and flavonoids such as rutin and quercetin. Leonurine plays a key role in its anti-inflammatory action by modulating inflammatory signaling pathways and cytokines, and by diminishing nuclear factor kappa B (NF-κB) function. This mechanism effectively suppresses various inflammatory substances and combats oxidative stress, while also demonstrating some antimicrobial activity.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Demonstrated significant antioxidant potential with over 60% DPPH radical scavenging activity in vitro.
- 02 Exhibited strong antioxidant activity with over 80% nitric oxide scavenging and 85% metal chelating activity in vitro.
- 03 Showed very good scavenging activity of hydroxyl radicals in vitro.
- 04 Displayed weak biostatic activity against Staphylococcus aureus, with its component ursolic acid showing stronger activity.
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
While generally considered safe in a broader context for topical use, there is insufficient specific data on topical sensitization. For internal use, Motherwort is associated with potential side effects including diarrhea, upset stomach, and uterine bleeding (at high doses of 3.0 grams/day). Oral consumption is considered likely unsafe during pregnancy due to uterine stimulation risks and can potentiate antithrombotic effects, increasing bleeding risk. These significant internal safety concerns warrant caution, especially for precision skincare brands.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Leonurus Cardiaca Extract is a valuable botanical ingredient offering significant antioxidant and anti-inflammatory potential beneficial for skin health, particularly for sensitive skin, though further in vivo topical efficacy studies would enhance its profile.
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