Science
Mechanism of Action
Leontopodium extract operates through a sophisticated mechanism, primarily as a potent antioxidant with a Radical Protection Factor (RPF) of 286, demonstrating twice the efficacy of Vitamin C. It effectively neutralizes free radicals and reactive oxygen species, safeguarding the skin from environmental oxidative stress induced by UV radiation and pollution. The extract exhibits significant anti-inflammatory properties, reducing skin irritation, redness, and discomfort, while simultaneously stimulating collagen synthesis and fortifying the skin barrier to improve firmness and elasticity. Additionally, it aids in maintaining optimal skin moisture balance by preventing transepidermal water loss and provides protection against blue light-induced cellular damage, specifically by influencing key gene expressions.
Research
Clinical Evidence
High confidence2%
Key findings
- 01 In vitro studies indicated that a 1% concentration of Leontopodium Alpinum callus culture extract (LACCE) provided superior radical-scavenging activity and inhibition of reactive oxygen species (ROS), comparable to N-acetyl cysteine. Activity was also noted at 0.1% and 0.5% concentrations.
- 02 Consistent clinical in vivo application of LACCE on facial skin led to measurable improvements in periorbital wrinkles, skin elasticity, dermal density, and overall skin thickness.
- 03 In vivo testing demonstrated that a water-based product containing 2% dry Leontopodium alpinum extract significantly increased hair density.
- 04 In vivo assessments of LACCE (marketed as Majestem) revealed a visible lifting action on the neck, reducing skin sagging by 10.6% to 56% within three weeks. Furthermore, crow's feet wrinkles were smoothed, showing a surface area reduction of 11% to 75% after six weeks.
Transparency
Dusting Analysis
While initial in vitro antioxidant activity has been observed at concentrations as low as 0.1%, robust clinical benefits for skin rejuvenation and elasticity are typically reported at concentrations ranging from 1% to 5%, with 2% to 3% often being optimal. Formulations containing less than 0.1% of this extract are unlikely to deliver the comprehensive benefits demonstrated in studies, making concentrations below this threshold a red flag for efficacy.
The Formula
Formulation
Safety
Safety Profile
Generally recognized as a well-tolerated ingredient with a high safety profile, this naturally derived extract rarely induces adverse reactions. While typically non-allergenic, individuals with sensitivities to other plant-derived materials should conduct a patch test prior to widespread use. Its application in cosmetics adheres to stringent regulatory standards; however, a formal CIR, SCCS, or FDA safety assessment specific to this extract was not identified in the provided research data.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Leontopodium extract is a highly valuable botanical ingredient, offering robust antioxidant protection, significant anti-aging benefits, and comprehensive skin conditioning properties, making it suitable across all skin types for targeted and visible improvements.
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