Science
Mechanism of Action
This extract operates through a multifaceted biological pathway, primarily via potent antioxidants like leontopodic acid and chlorogenic acid. These compounds efficiently neutralize free radicals, safeguarding cellular structures from oxidative stress induced by UV radiation and pollution, thus mitigating premature aging. Its anti-inflammatory action reduces redness and irritation, fostering a calmer skin environment. Leontopodic acid further reinforces the skin's natural barrier, improving resilience and moisture retention. Additionally, it supports collagen synthesis and inhibits the degradation of collagen and elastin, critical for maintaining skin's firmness, elasticity, and minimizing the appearance of fine lines and wrinkles, while also encouraging skin regeneration.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 In an in vivo study, a leave-on serum containing 0.06% Edelweiss dry extract significantly increased hair density and extended the anagen growth phase. A concentration as low as 0.001% also demonstrated anagen phase prolongation in ex vivo human hair follicles.
- 02 Leontopodium Alpinum callus culture extract (LACCE) concentrations ranging from 0.1% to 1% improved cell viability by 45.54% to 60.37% against hydrogen peroxide-induced oxidative stress in HaCaT cells in vitro, with 1% showing superior radical-scavenging activity. In a clinical in vivo test, consistent topical application of LACCE visibly reduced periorbital wrinkles and enhanced skin elasticity, dermal density, and thickness.
- 03 Manufacturer claims for a specific Leontopodium Alpinum Callus Culture Extract (Majestem) report a measurable lifting effect, with neck sagging reduced by 10.6% to 56% within three weeks. After six weeks, improvements were noted in cheek lifting and crow's feet wrinkle surface reduction (11% to 75%).
Transparency
Dusting Analysis
The Formula
Formulation
Stability
This extract is typically prepared in an ethanol/water (60/40 w/w) solution. For optimal shelf life, refrigeration after opening is advised, with storage temperatures not exceeding 25°C (77°F). It should be protected from freezing, excessive heat or cold, and light exposure. For formulation, ensure even blending into products or add to the water phase of preparations.
Safety
Safety Profile
Leontopodium Alpinum extract is generally considered to possess an excellent safety profile, demonstrating good tolerance across most skin types with infrequent reports of allergic reactions. Its use in cosmetics adheres to rigorous safety standards. However, individuals with known sensitivities to other botanical ingredients are advised to perform a patch test. While listed as 'Restricted' by EWG Skin Deep® for EWG VERIFIED™ products without sufficient substantiation, this pertains to specific verification criteria and not a general safety concern.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Leontopodium Alpinum Root Extract is a valuable botanical ingredient, offering comprehensive antioxidant protection, significant anti-aging benefits, and soothing properties suitable for all skin types with a low risk of irritation.
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