Science
Mechanism of Action
This extract, rich in leontopodic and chlorogenic acids, acts as a potent antioxidant, neutralizing free radicals and mitigating oxidative stress from UV and pollution. Its anti-inflammatory action suppresses markers like COX-2, iNOS, and various cytokines (GM-CSF, IP-10, MCP-1, IL-8), reducing irritation and redness. Anti-aging benefits stem from promoting skin regeneration, preserving elasticity, boosting dermal density, and protecting collagen and elastin from degradation. Furthermore, it aids in skin barrier function, moisture retention, may offer antibacterial effects, mitigate blue-light damage, reduce glycation, activate sirtuins, and contribute to brightening by addressing hyperpigmentation.
Research
Clinical Evidence
High confidence1%
Key findings
- 01 1% Leontopodium Alpinum Callus Culture Extract (LACCE) demonstrated potent reactive oxygen species (ROS) inhibition comparable to N-acetyl cysteine, and superior DPPH radical-scavenging activity of 20.47% compared to 14.05% for Vitamin C.
- 02 In primary human keratinocytes, 25 μg/mL prevented a decrease in cell proliferation after simulated UVA+UVB irradiation, indicating photoprotective benefits.
- 03 In vitro studies showed significant anti-inflammatory effects by inhibiting the release of inflammatory markers (GM-CSF, IP-10, MCP-1, IL-8) from primary human keratinocytes, with IC50 values ranging from 43 to 72 μg/mL.
- 04 Clinical in vivo testing of LACCE improved anti-periorbital wrinkles (decreasing Ra by 6.118% and Rq by 6.189% at four weeks), enhanced skin elasticity, and increased dermal density and skin thickness compared to placebo.
- 05 A specialized Leontopodium alpinum callus culture extract (Majestem) visibly reduced sagging skin on the neck by 10.6% to 56% in three weeks, and smoothed crow's feet wrinkles (surface reduction of 11% to 75%) while lifting cheeks after six weeks.
Transparency
Dusting Analysis
A 1% concentration of a related extract (LACCE) has demonstrated significant antioxidant efficacy, suggesting that effective concentrations are well within typical formulation ranges and dusting is not a common concern for this ingredient.
The Formula
Formulation
Stability
For extended shelf life, refrigeration is recommended after opening. Store below 77°F (25°C) and avoid freezing.
Conflicts
- Vitamin C (consider separate application due to high intrinsic antioxidant activity, not a direct incompatibility)
- Copper Peptides (recommended for separate use)
- Retinol (recommended for separate use)
Safety
Safety Profile
This naturally derived extract generally boasts a high safety profile, with EWG Skin Deep rating it 'LOW' for concerns like cancer, allergies, immunotoxicity, and reproductive toxicity. While typically non-allergenic, individuals with sensitivities to other plant materials should perform a patch test. It adheres to strict cosmetic safety regulations.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Leontopodium Alpinum Flower/Leaf/Stem Extract is a highly valuable botanical ingredient offering comprehensive antioxidant, anti-inflammatory, and anti-aging benefits for a wide range of skin types with a favorable safety profile.
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References
Sources