Science
Mechanism of Action
This potent ingredient functions primarily as a robust antioxidant, actively neutralizing free radicals and mitigating oxidative stress from environmental aggressors, UV radiation, and pollution. It stimulates the production of vital structural proteins like collagen, improves skin barrier function, and promotes cellular regeneration, leading to enhanced firmness and elasticity. Furthermore, it exhibits anti-inflammatory properties, maintains skin hydration through humectant action, offers DNA protection, inhibits hyaluronidase to preserve dermal integrity, and specifically defends against blue light-induced damage. Its antimicrobial capabilities also contribute to overall skin health by managing microbial growth.
Research
Clinical Evidence
High confidence1%
Key findings
- 01 In vivo clinical tests demonstrated that constant application of Leontopodium Alpinum Callus Culture Extract (LACCE) significantly improved anti-periorbital wrinkles, skin elasticity, dermal density, and skin thickness when compared with a placebo. This suggests a direct impact on visible signs of aging.
- 02 In a blue-light-induced human foreskin fibroblast damage model, LACCE at concentrations of 10–15 mg/mL promoted collagen (COL-I) production and inhibited the secretion of matrix metalloproteinase 1 (MMP-1), opsin 3 (OPN3), reactive oxygen species (ROS), and calcium influx. This indicates a protective action against digital aging and the preservation of skin structural integrity.
Transparency
Dusting Analysis
Specific data on dusting analysis, including common practices, thresholds, or red flag percentages for this ingredient, is not available in the provided research.
The Formula
Formulation
Stability
While the optimal pH range for stability in cosmetic formulations is not explicitly detailed in the available research, its active components are generally incorporated into water or glycerin-based extracts, suggesting good water compatibility. The callus culture propagation process is noted to occur efficiently within a pH range of 5.8 to 6.5.
Safety
Safety Profile
Leontopodium Alpinum Callus Culture Extract exhibits an excellent safety profile, being well-tolerated across most skin types with rare reports of allergic reactions. European cosmetic regulatory bodies classify it as safe for cosmetic use without imposing special restrictions. Official CIR or FDA review status for this specific ingredient was not found.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Leontopodium Alpinum Callus Powder is a valuable multi-functional ingredient, offering robust anti-aging, protective, and hydrating benefits across all skin types with a favorable safety profile.
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References
Sources