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Moumoujus

LEONTOPODIUM ALPINUM CALLUS LYSATE.

Valuable / SKIN CONDITIONING

Leontopodium Alpinum Callus Lysate, derived from Edelweiss plant stem cells, is a potent ingredient engineered to protect skin from environmental stressors, visibly lift and firm, and diminish signs of aging. It delivers significant antioxidant defense, strengthens the skin barrier, and promotes collagen production for improved elasticity and dermal density.

Summary

antioxidant skin protecting soothing anti-aging firming collagen boosting barrier strengthening blue light protection

Science

Mechanism of Action

This ingredient operates on multiple cellular levels to enhance skin resilience and vitality. It acts as a powerful antioxidant by effectively neutralizing free radicals and inhibiting the OPN3 receptor and subsequent Reactive Oxygen Species (ROS) oxidative stress, particularly in response to blue light exposure. Furthermore, it actively promotes the synthesis of Type I Collagen (COL-I) while simultaneously inhibiting Matrix Metalloproteinase-1 (MMP-1), an enzyme responsible for collagen degradation, thereby preserving the skin's structural integrity. The active compound, leontopodic acid, is believed to contribute to its anti-inflammatory properties. It also supports skin barrier function by up-regulating genes involved in keratinization and cornification, leading to improved moisture retention, reduced inflammation, and overall enhanced skin thickness and elasticity.

Research

Clinical Evidence

High confidence
Effective range 0.1–1%
Optimal

0.1%

Key findings

  1. 01 A 2023 MDPI study demonstrated that Leontopodium Alpinum Callus Lysate, at concentrations of 10-15 mg/mL, significantly mitigated blue light-induced damage in human foreskin fibroblast cells. This was achieved by inhibiting MMP-1 production, promoting COL-I secretion, and suppressing OPN3 receptor activation and ROS oxidative stress response.
  2. 02 Research from PMC (2020) indicated that concentrations between 0.1-1% effectively increased cell viability and inhibited reactive oxygen species (ROS) production when cells were exposed to hydrogen peroxide, confirming its robust antioxidant activity.
  3. 03 In *in-vivo* clinical tests (using the trade name Majestem), this ingredient delivered visible lifting and firming effects on the neck and face. Sagging neck skin was tightened by -10.6% up to -56% within three weeks, while after six weeks, cheeks appeared lifted and crow's feet wrinkles showed a surface reduction of -11% up to -75%.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

The callus extract preparation process involves distilled water and heat extraction. While the pH of the MS medium for callus culture was adjusted to 5.8, specific optimal pH ranges for stability in finished cosmetic formulations are not detailed in the available research.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Leontopodium Alpinum Callus Lysate is considered to have an excellent safety profile, being well-tolerated by most skin types and rarely causing allergic reactions. European cosmetic regulatory bodies deem it safe for cosmetic use without special restrictions. COSMILE Europe indicates 'No penalty' across all safety categories. No specific CIR or FDA safety status has been established.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Leontopodium Alpinum Callus Lysate is a highly valuable multi-functional ingredient, clinically proven to offer significant anti-aging, firming, antioxidant, and blue light protective benefits for comprehensive skin health across all skin types.

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