Science
Mechanism of Action
This extract functions as a robust antioxidant, actively neutralizing free radicals and mitigating damage from UV radiation, pollution, and blue light by reducing reactive oxygen species. Its anti-aging efficacy stems from stimulating collagen synthesis, fortifying the skin's natural barrier, and improving moisture retention, which collectively contributes to enhanced firmness, elasticity, and a reduction in fine lines and wrinkles. Furthermore, compounds like leontopodic acid confer anti-inflammatory benefits, soothing irritation and modulating inflammatory pathways, potentially through sirtuin activation, to promote overall skin regeneration and health.
Research
Clinical Evidence
High confidence1%
Key findings
- 01 1% concentration demonstrated significant in-vivo improvements in periorbital wrinkles, skin elasticity, dermal density, and skin thickness.
- 02 Increased cell viability by 45.54% at 0.1% and 60.37% at 1% when exposed to hydrogen peroxide, indicating cellular protection. 1% concentration also showed 20.47% DPPH radical-scavenging activity.
- 03 10-15 mg/mL inhibited MMP-1 production and promoted COL-I secretion in human foreskin fibroblasts exposed to blue light, indicating protection against digital aging.
- 04 25 µg/mL protected primary human keratinocytes from solar UVA+UVB-induced damage and boosted early intracellular nitric oxide levels.
- 05 10-50 µg/mL dose-dependently suppressed TNFα + IFNγ-induced chemokine (IL-8, IP-10, MCP-1) and growth factor release from primary human keratinocytes, highlighting its anti-inflammatory action.
- 06 In-vivo tests of a specific formulation showed visible lifting on the neck and face, tightening sagging neck skin by -10.6% up to -56% in three weeks, and smoothing crow's feet wrinkles by -11% up to -75% after six weeks.
Transparency
Dusting Analysis
While some cellular benefits are observed at 0.1%, optimal in-vivo anti-aging and antioxidant efficacy are demonstrated at 1%. Concentrations below 0.1% are unlikely to provide significant measurable benefits, with amounts under 0.05% considered largely ineffective.
The Formula
Formulation
Stability
To maintain integrity, protect the extract from direct light exposure and refrigerate after opening. It should be added to the water phase of formulations.
Conflicts
- Vitamin C
- Copper Peptides
- Retinol
Safety
Safety Profile
Leontopodium Alpinum Callus Extract is generally well-tolerated across most skin types, with a low incidence of irritation or allergic reactions. European cosmetic regulations do not impose specific usage restrictions.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Leontopodium Alpinum Callus Extract is a valuable, multifaceted ingredient offering significant antioxidant defense, proven anti-aging benefits, and soothing properties, making it highly compatible with all skin types for comprehensive skin improvement.
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