Science
Mechanism of Action
This extract operates through multiple precise pathways: it exhibits potent antioxidant activity by decreasing reactive oxygen species (ROS) and calcium influx, safeguarding skin cells from oxidative stress. Specifically, at concentrations of 10-15 mg/mL, it significantly inhibits matrix metalloproteinase 1 (MMP-1), an enzyme responsible for collagen degradation, and simultaneously promotes the secretion of collagen type I (COL-I). It also inhibits opsin 3 (OPN3) to prevent blue light damage. Beyond these actions, the extract, rich in compounds like leontopodic and chlorogenic acids, provides anti-inflammatory benefits, supports a balanced skin microbiome by inhibiting bacteria, and enhances overall dermal structure and moisture retention.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 In human foreskin fibroblast cells, a concentration of 10-15 mg/mL significantly inhibited the production of matrix metalloproteinase 1 (MMP-1), opsin 3 (OPN3), reactive oxygen species (ROS), and calcium influx, while promoting collagen (COL-I) secretion, demonstrating an anti-blue-light-damage effect.
- 02 Consistent application on facial skin tissues led to measurable improvements in anti-periorbital wrinkles, skin elasticity, dermal density, and skin thickness, outperforming a placebo.
- 03 Manufacturer claims (for the trade name Majestem) reported a visible lifting action on the neck and face, with sagging skin on the neck tightening by -10.6% up to -56% within three weeks. After six weeks, cheeks were also observed to be lifted, and crow's feet wrinkles were smoothed, showing a surface area reduction of -11% up to -75%.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
For optimal longevity, it is recommended to refrigerate the contents after opening and store the product at temperatures not exceeding 77°F (25°C), avoiding freezing or exposure to excessive heat or cold.
Safety
Safety Profile
Leontopodium Alpinum Callus Culture Extract demonstrates an excellent safety profile, being well-tolerated across most skin types with rare instances of allergic reactions. European cosmetic regulatory bodies consider it safe for use without special restrictions. Minor skin reactions like redness or itching are extremely uncommon, though a patch test is always advisable. SkinSAFE classifies this ingredient as 'Irritant Free'.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Valuable, Leontopodium Alpinum Callus Culture Extract delivers robust anti-aging and protective benefits through collagen stimulation, blue light defense, and overall skin barrier enhancement, making it a powerful addition to comprehensive skincare formulations.
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