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Moumoujus

LEDUM PALUSTRE EXTRACT.

Insufficient Data CAS 90063-39-1 / FRAGRANCE, TONIC

Ledum Palustre Extract is a botanical ingredient recognized for its multifaceted benefits, including potent anti-inflammatory and antioxidant activities. It also offers antimicrobial and antiseptic properties, making it beneficial for soothing irritated skin and supporting overall dermal health.

Summary

Anti-inflammatory Antioxidant Antimicrobial Antiseptic Wound Healing Support Swelling Reduction Masking Tonic

Science

Mechanism of Action

Ledum Palustre Extract operates through several key mechanisms: its rich composition of flavonoids and essential oils modulates inflammatory responses by reducing pro-inflammatory markers. It provides antioxidant defense by scavenging free radicals, thereby mitigating oxidative stress at the cellular level. Furthermore, it exhibits antimicrobial and antiseptic actions against various pathogens, assisting in the management of minor skin infections and promoting natural wound healing. The essential oil component may also enhance transdermal skin permeation.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Demonstrated high antioxidant activities, achieving 82.3% inhibition in DPPH assays and 99.8% in ABTS assays.
  2. 02 Exhibited excellent anti-inflammatory activities in LPS-stimulated Raw 264.7 macrophages, inhibiting nitric oxide (NO) by 50-57%, prostaglandin E2 (PGE2) by 70-73%, TNF-α by 24-51%, IL-1β by 47-57%, and IL-6 by 40-62%.
  3. 03 Maintained cell viability above 90% in cytotoxicity evaluations on macrophages, indicating good tolerability at effective concentrations.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

For optimal stability, store away from direct light, extreme temperatures, humidity, and strong scents. Ensure the container is tightly capped.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) Expert Panel has not evaluated Ledum Palustre Extract for cosmetic use. The plant contains ledol, a toxic sesquiterpenoid, which has limited its internal use; however, topical application of its essential oil is referenced. The FDA lists homeopathic products containing Ledum palustre but explicitly states they are 'not evaluated by the Food and Drug Administration for safety or efficacy' and does not acknowledge scientific evidence supporting homeopathy as effective for its claimed uses.

Your Skin

Skin Compatibility

Yes Normal
No Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While exhibiting robust antioxidant and anti-inflammatory activities in vitro, Ledum Palustre Extract currently lacks comprehensive safety evaluation by the CIR Expert Panel, necessitating further research for its widespread application in precision skincare.

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