Science
Mechanism of Action
This extract exerts its benefits primarily through antioxidant action, attributed to its rich content of phenolic compounds and flavonoids. Its anti-inflammatory effects stem from the inhibition of nitric oxide (NO) release in inflammatory pathways. Additionally, it demonstrates anti-seborrheic activity, helping to regulate sebum synthesis and/or secretion, which contributes to improved skin appearance. The extract may also play a role in initiating dermal remodeling mechanisms.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 In vitro studies on LPS-stimulated RAW 264.7 macrophages demonstrated significant anti-inflammatory activity, with methanolic extracts inhibiting NO release by 28% (from twigs) and 17% (from leaves) at a concentration of 25 µg/ml.
- 02 Both twig and leaf methanolic extracts exhibited strong antioxidant activity through ORAC and cell-based assays in vitro.
- 03 A cosmetic patent application highlights the extract's ability to improve skin radiance, reduce dullness, enhance complexion, and overall skin appearance, particularly beneficial for oily, mixed, and acne-prone skin types.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The essential oil component of Ledum Groenlandicum may slowly oxidize upon exposure to air. The extract is stable under typical temperatures and storage conditions but should be shielded from excessive heat, open flames, sparks, and strong oxidizing agents. The natural pH range of the plant's habitat waters is between 4 and 8.
Conflicts
- strong oxidizing agents
Safety
Safety Profile
EWG Skin Deep assesses Ledum Groenlandicum Extract as 'LOW' hazard regarding cancer, allergies/immunotoxicity, and developmental/reproductive toxicity. However, EWG VERIFIED™ products mandate adequate substantiation for its use. The essential oil component derived from Ledum Groenlandicum has been noted to potentially cause skin irritation and allergic reactions. Safety data for topical use during pregnancy, nursing, or for individuals younger than 2 years is not sufficiently established. It's important to differentiate the topical extract from the Labrador tea beverage, which carries toxicity concerns (ledol and grayanotoxin) if consumed more than once daily.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Ledum Groenlandicum Extract is a valuable ingredient, particularly for oily and acne-prone skin, offering proven antioxidant and anti-inflammatory benefits, along with documented improvements in skin radiance and complexion when formulated carefully to mitigate potential essential oil sensitivities.
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References
Sources