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LEDEBOURIELLA SESELOIDES ROOT EXTRACT.

Valuable CAS - / SKIN CONDITIONING

Sourced from the root of the Ledebouriella seseloides plant, this botanical extract is recognized for its potent antioxidant and anti-inflammatory properties. Historically valued in Traditional Chinese Medicine for its soothing and anti-itching effects, it actively contributes to skin conditioning and overall dermal balance.

Summary

Skin conditioning Antioxidant Anti-inflammatory Soothing Antimicrobial Anti-itching Immunomodulatory

Science

Mechanism of Action

This root extract operates through multiple pathways to support skin health. Its primary mechanism involves powerful antioxidant and anti-inflammatory actions, which mitigate cellular damage and soothe irritation. Bioactive compounds, including coumarins and chromones, are believed to modulate immune responses by significantly reducing nitric oxide production in activated immune cells, thereby calming inflammatory processes. It also exhibits antimicrobial characteristics and functions as a skin conditioning agent.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 An in vitro study demonstrated significant antioxidant capabilities and dose-dependent anti-inflammatory effects, specifically showing a reduction in nitric oxide production in LPS-activated RAW 264.7 cells. The extract (prepared as 1 g/10 ml 70% ethanol) also exhibited anti-proliferative activity against certain human tumor cell lines at dilutions ranging from 1/300 to 1/10000.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

The extract is water-soluble and demonstrates good dispersibility in aqueous and hydroalcoholic systems, indicative of its stability in common cosmetic formulations. It is often prepared through cold maceration using solvents like ethanol, glycerin, and purified water.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) has not specifically evaluated Ledebouriella Seseloides Root Extract. It holds a 'non-approved' record status in the FDA Global Substance Registration System, which is standard for cosmetic ingredients not classified as drugs. However, a common synonym, Ledebouriella Divaricata Root Extract, is rated 'LOW' by EWG Skin Deep across categories including cancer risk, allergies/immunotoxicity, and developmental/reproductive toxicity, suggesting a favorable overall safety profile.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

This well-tolerated root extract offers valuable antioxidant and anti-inflammatory benefits, making it an excellent ingredient for soothing and conditioning all skin types.

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