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LARREA DIVARICATA LEAF EXTRACT.

Valuable CAS 91722-67-7 / SKIN CONDITIONING

Larrea Divaricata Leaf Extract is a versatile botanical known for its significant antioxidant and anti-inflammatory capabilities. It effectively combats oxidative stress, reduces skin redness, and fosters a more balanced and revitalized complexion. This extract is particularly beneficial for addressing concerns ranging from signs of aging to blemish prevention.

Summary

Antioxidant Anti-inflammatory Anti-acne Anti-aging Antibacterial Wound Healing Sebum Regulation Hair Growth Inhibition

Science

Mechanism of Action

This extract operates by effectively neutralizing free radicals and significantly reducing inflammation, thereby safeguarding skin from oxidative damage and mitigating visible signs of aging, such as fine lines and age spots. A key component, Nordihydroguaiaretic Acid (NDGA), contributes to anti-proliferative effects, which can moderate hair regrowth, and exhibits senolytic properties by inducing the death of senescent cells, enhancing anti-aging benefits. Furthermore, its antibacterial and antiseptic qualities are advantageous for oily and blemish-prone skin, preventing the oxidation of oils that contribute to blackhead formation. It also promotes wound healing by stimulating keratinocyte and fibroblast proliferation and protecting these cells from oxidative damage.

Research

Clinical Evidence

Medium confidence
Effective range 10 µg/ml–100 µg/ml%
Optimal

N/A

Key findings

  1. 01 In *in vitro* macrophage studies, this concentration substantially reduced glucose-induced lipid peroxidation by 17%, nitric oxide by 47-50%, TNF-α by 32%, and free radicals by 50%, underscoring its robust antioxidant and anti-inflammatory properties.
  2. 02 Aqueous extracts demonstrated inhibitory activity against both susceptible and resistant *Helicobacter pylori* strains, indicating its antibacterial potential.
  3. 03 Aqueous extracts naturally contain Nordihydroguaiaretic Acid (NDGA) within this range, which is attributed to many of its observed biological activities.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Aqueous extracts have been shown to maintain stability during incubation at 37°C across a pH range of 1.2, 6.8, and 7.0.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) and Scientific Committee on Consumer Safety (SCCS) have not specifically assessed Larrea Divaricata Leaf Extract. While Nordihydroguaiaretic Acid (NDGA), a primary component, was once prohibited by the FDA as a food preservative due to hepatotoxic effects at high oral doses, *in vivo* studies on aqueous extracts of Larrea Divaricata demonstrated low acute toxicity. A dose of 33.4 mg/kg showed no hepatotoxicity or nephrotoxicity in mice, with an aqueous extract lethal dose 50 (LD50) reported at 40,000 mg/kg, suggesting a significant safety margin for topical applications of the extract itself. The Good Scents Company reports 'None found' for GHS classification and toxicity data for the extract.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Larrea Divaricata Leaf Extract is a valuable botanical ingredient offering robust antioxidant, anti-inflammatory, and antimicrobial benefits for diverse skin types, supporting anti-aging and blemish-prone concerns.

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