Science
Mechanism of Action
This extract operates through several pathways to promote skin health. It acts as an antioxidant by directly scavenging free radicals and by activating the p38/c-Jun N-Terminal Kinase–Nuclear Factor Erythroid 2-Related Factor 2 (p38/JNK–NRF2)-Mediated Antioxidant Pathway, which upregulates Heme Oxygenase 1 (HO-1) expression to reduce oxidative stress. Its anti-inflammatory action involves mitigating inflammatory cell infiltration. Furthermore, it exhibits significant antimicrobial efficacy, particularly against gram-positive bacteria and Methicillin-resistant Staphylococcus aureus (MRSA). The presence of tannins contributes to its traditional use as an astringent.
Research
Clinical Evidence
Medium confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
Toxicology assessments in animals indicated a high safety margin, with no observed toxicity or mortality at oral doses exceeding 3000 mg/kg. The LD50 value of the leaf extract was reported to be greater than 5000 mg/kg BW, suggesting a non-toxic practical category. Acute toxicity and histopathological studies indicate the extract is biocompatible. Specific safety assessments by CIR, SCCS, or FDA for topical Lannea Coromandelica Bark Extract are not available.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Lannea Coromandelica Bark Extract presents as a valuable multi-functional ingredient with promising in vitro and animal data for antioxidant, anti-inflammatory, and antimicrobial benefits, making it suitable for a range of skin concerns despite the current lack of human topical efficacy studies.
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