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LAMIUM PURPUREUM EXTRACT.

Valuable / HUMECTANT, SKIN CONDITIONING

Lamium Purpureum Extract is a multi-functional botanical ingredient, rich in flavonoids and phenolic acids. It offers robust antioxidant protection by effectively scavenging free radicals and exhibits significant antimicrobial properties. Furthermore, it functions as a skin conditioning agent, contributing to hydration, sebum regulation, and potential soothing benefits for various skin types.

Summary

Antioxidant Antimicrobial Skin Conditioning Humectant Astringent

Science

Mechanism of Action

This extract exerts its effects through several key mechanisms: Its primary action is robust antioxidant activity, attributed to bioactive compounds like flavonoids and phenolic acids, which efficiently scavenge free radicals as evidenced in DPPH, ABTS, FRAP, and TRP assays. It also demonstrates antimicrobial, anti-quorum sensing, and antibiofilm capacities by inhibiting pathogens like *Escherichia coli* and *Candida guilliermondii*. While direct *Lamium purpureum* anti-inflammatory studies are limited in this data, related species like *Lamium album*, sharing similar phytochemicals, exhibit anti-inflammatory effects by downregulating the NF-κB pathway and reducing inflammatory cytokines. Moreover, components such as mucilages and tannins act as skin conditioning agents, supporting hydration, regulating sebum production, and forming a protective epidermal layer.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 A 1% butanolic extract of Lamium purpureum demonstrated superior free radical scavenging, achieving 95.53% inhibition against DPPH radicals in an *in vitro* assay.
  2. 02 Various solvent extracts (methanol, ethanol, ethyl acetate, chloroform) of Lamium purpureum exhibited dose-dependent antioxidant and free radical scavenging activities across DPPH, ABTS, FRAP, and TRP *in vitro* assays, with the methanol extract showing the highest reducing capacity (0.0132 mg AA/mL).
  3. 03 An ethanol extract at 100 mg/mL demonstrated significant anti-pathogenic properties *in vitro*, inhibiting *Escherichia coli* biofilm formation by 89.66% and *Candida guilliermondii* yeast growth with a 27.5±0.71 mm inhibitory zone.
  4. 04 An ointment containing 5% methanol extract of *Lamium album* (a related species) significantly improved wound healing in a rat model by enhancing fibroblast maturation, collagen deposition, and neovascularization.

Transparency

Dusting Analysis

Not commonly dusted

The provided research data does not contain information regarding dusting potential or specific dusting thresholds for Lamium Purpureum Extract.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

No specific optimal pH range for stability has been identified. However, antioxidant assays were successfully conducted under buffered conditions at pH 6.6 (phosphate buffer) and pH 7.8 (sodium carbonate buffer.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Lamium Purpureum Extract has not undergone specific safety review by CIR or SCCS. However, extracts from the Lamium genus, such as Lamium album, are generally considered safe for cosmetic applications with low irritation risk. *In vitro* studies on *Lamium album* extracts showed no toxic effects on normal human skin fibroblasts at concentrations up to 225 μg/ml.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Lamium Purpureum Extract is a valuable ingredient offering potent antioxidant, antimicrobial, and skin conditioning benefits, supported by promising *in vitro* and related species *in vivo* data, indicating broad compatibility across skin types.

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