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LACTOCOCCUS/LAC FERMENT LYSATE.

Valuable / SKIN CONDITIONING

Lactococcus/Lac Ferment Lysate is a sophisticated postbiotic ingredient derived from fermented bacteria. It is engineered to fortify the skin's inherent barrier function, enhance resilience against environmental aggressors, and maintain a balanced skin microbiome.

Summary

skin conditioning antioxidant moisturizer/humectant

Science

Mechanism of Action

This postbiotic ingredient works by stimulating skin cell regeneration and strengthening the skin's protective layer. It positively influences gene expression, specifically increasing proteins vital for binding live skin cells together, such as Occludin, Desmocollin 1, and Desmoglein 1. Simultaneously, it modulates enzymes (Kallikrein 5 and 7) involved in the shedding of dead skin cells. This dual action supports epidermal growth, leads to a thicker stratum corneum, and enhances the skin's immunocompetence through the stimulation of antimicrobial peptides. The result is improved skin defense, reduced irritation, and a balanced microbiome.

Research

Clinical Evidence

Medium confidence
Effective range 3–5.6%
Optimal

N/A

Key findings

  1. 01 An in-vivo study utilizing 3% Lactococcus/Lac Ferment Lysate twice daily demonstrated a measurable increase in stratum corneum thickness (approximately 2 µm) and a reduction in trans-epidermal water loss within 4 days, following barrier disruption via tape stripping.
  2. 02 A product containing 5% Lactobacillus Ferment Lysate Filtrate (a related ingredient) was evaluated at 100% concentration in Human Repeat Insult Patch Tests (HRIPTs) involving 50 subjects, confirming its non-irritating and non-sensitizing profile.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 6
0 7 14

Stability

This ingredient is water-soluble and best incorporated into water-based formulations or the water phase of emulsions. For optimal stability, it is advisable to add it during the cooling phase, at temperatures below 70°C (158°F), and prior to the inclusion of thickeners. It performs optimally within a pH range of 5.0 to 6.0, though related ferment lysates can tolerate a broader range.

Safety

Safety Profile

CIR Status
Safe as used
Max tested
5.6%
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has affirmed the safety of Lactococcus/Lac Ferment Lysate and related Lactobacillus ferments as used in cosmetics. It possesses a favorable safety profile, is generally well-tolerated, and adverse reactions are rare. While its maximum reported use concentration in skincare is up to 5.6%, a patch test is still recommended for individuals with known skin sensitivities.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Lactococcus/Lac Ferment Lysate is a valuable postbiotic ingredient for enhancing skin barrier function, supporting regeneration, and balancing the microbiome, suitable for all skin types due to its proven efficacy and low sensitization risk.

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