Science
Mechanism of Action
This postbiotic ingredient influences the skin at a cellular level, stimulating the gene expression of crucial proteins like Occludin, Desmocollin 1, and Desmoglein 1, which are vital for maintaining robust tight junctions between live epidermal cells. Concurrently, it activates enzymes such as Kallikrein 5 and 7, facilitating the controlled breakdown of bonds between shedding dead skin cells to support efficient natural renewal. Furthermore, it boosts the production of antimicrobial peptides, essential for the skin's immunocompetence and maintaining a healthy microflora. These integrated actions lead to improved epidermal growth, enhanced barrier recovery, superior moisture retention, and increased resilience against environmental aggressors, ultimately mitigating visible signs of aging, reducing irritation, and balancing the skin's microbiome.
Research
Clinical Evidence
High confidence5%
Key findings
- 01 In an in-vivo study, twice-daily application for 4 days resulted in a measurable thickening of the stratum corneum by approximately 2 µm and a reduction in trans-epidermal water loss (TEWL), demonstrating improved skin renewal and enhanced barrier recovery.
- 02 A double-blind, randomized controlled trial with 70 participants over 6-8 weeks revealed that a topical formulation containing 5% Lactococcus Ferment Lysate significantly reduced the severity of acne vulgaris, decreased sebum levels (evident on the forehead by week 6, and cheeks by week 8), lowered pro-inflammatory cytokines, and enhanced anti-inflammatory cytokines.
- 03 A lotion incorporating VHProbi® Mix R, which includes Lactococcus Ferment Lysate, applied twice daily for 30 days, demonstrably decreased transepidermal water loss (TEWL) and redness, while increasing skin moisturization. This led to a reinforced skin barrier function and alleviated symptoms associated with sensitive skin.
Transparency
Dusting Analysis
The provided research data does not contain information regarding ingredient dusting practices or thresholds for Lactococcus Ferment Lysate.
The Formula
Formulation
Stability
Lactococcus Ferment Lysate is completely soluble in water, making it well-suited for aqueous formulations and for incorporation into the water phase of emulsions. For optimal stability and to fully leverage its antimicrobial properties, a pH range of 3.0-7.0 is recommended, although it remains compatible within formulations maintaining a pH range of 3.0-8.0. It is advised to add the ingredient during the cooling phase, ensuring temperatures are below 70°C (158°F), and prior to the addition of thickeners.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel has concluded that Lactococcus Ferment Lysate, alongside related Lactobacillus ferment ingredients, is safe for use in cosmetics. Assays performed on a related ingredient, Lactobacillus Ferment Lysate, at 100% concentration, indicated it to be non-irritating. Further, FDA VCRP data supports the widespread use of similar ferment ingredients in various cosmetic formulations. Clinical studies have specifically demonstrated the efficacy and safety of Lactococcus Ferment Lysate at concentrations up to 5%.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Lactococcus Ferment Lysate is an essential postbiotic for comprehensive skin health, proven to enhance barrier function, support renewal, balance the microbiome, and effectively address concerns from acne and sensitivity to environmental damage and visible signs of aging.
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