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LACTOCOCCUS FERMENT.

Valuable / SKIN CONDITIONING

Lactococcus Ferment Lysate is a postbiotic ingredient derived from the controlled fermentation of Lactococcus bacteria. It is engineered to bolster the skin's natural defense mechanisms, promote cellular renewal, and cultivate a balanced, resilient skin microbiome.

skin conditioning barrier repair anti-inflammatory microbiome balancing cell regeneration acne treatment

Science

This ingredient actively strengthens the skin's natural barrier by stimulating epidermal cell regeneration and enhancing the expression of crucial proteins responsible for intercellular binding, such as Occludin, Desmocollin 1, and Desmoglein 1. It also positively influences epidermal quality by stimulating enzymes like Kallikrein 5 and 7, which are involved in the healthy shedding of dead skin cells. By balancing the skin's microflora, Lactococcus Ferment Lysate reduces inflammation, minimizes sensitivity, redness, and dryness, and promotes the production of antimicrobial peptides, thereby enhancing the skin's overall resilience against external stressors.


Research

Medium confidence
Effective range 3–5%
Optimal

N/A

Key findings

  1. 01 A 3% concentration of Lactococcus Ferment Lysate, applied twice daily for four days, resulted in a ~2 µm increase in stratum corneum thickness and reduced transepidermal water loss, indicative of enhanced barrier recovery and overall skin renewal.
  2. 02 Topical formulations containing 5% Lactococcus Ferment Lysate demonstrated a reduction in acne vulgaris severity, decreased sebum levels, and modulated cytokine profiles by lowering pro-inflammatory and enhancing anti-inflammatory markers.

Transparency

Not commonly dusted

The Formula

Solubility
Water
Optimal pH 3 – 8
0 7 14

Stability

Lactococcus Ferment is water-soluble and integrates effectively into water-based systems or the water phase of emulsions within a pH range of 3.0-8.0. For optimal stability and activity, it is recommended to incorporate the ingredient during the cooling phase, at temperatures below 70°C, and prior to the addition of thickening agents.


Safety

CIR Status
Not reviewed
Sensitization risk Low

While Lactococcus Ferment itself has not been specifically reviewed by the Cosmetic Ingredient Review (CIR) Expert Panel, closely related ingredients such as Lactobacillus Ferment and its derivatives have been deemed safe for cosmetic use. Generally, Lactococcus Ferment Lysate exhibits a favorable safety profile with low potential for adverse reactions, though individual sensitivities are always possible.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

This postbiotic ingredient offers significant benefits for skin barrier integrity, cellular renewal, and microbiome balance across various skin types, making it a valuable addition to precision skincare formulations.


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