Science
Mechanism of Action
Operating as a sophisticated ferment filtrate, this ingredient functions by providing a spectrum of highly bioavailable postbiotic metabolites to the skin. These active components are scientifically recognized for their potent antioxidant capabilities, effectively scavenging free radicals and protecting against H2O2-induced oxidative stress. Beyond antioxidant defense, these metabolites work to mitigate inflammation, reinforce the skin's natural barrier function, significantly improve hydration levels, refine skin texture, and contribute to a balanced and healthy skin microbiome.
Research
Clinical Evidence
Low confidenceN/A
Key findings
- 01 A fermented Stevia Leaf Extract, at a concentration of 250 µg/mL, exhibited substantially enhanced antioxidant activity (measured via DPPH and ABTS radical scavenging, and protection against H2O2-induced oxidative stress in HEK-293 cells) when compared to its unfermented equivalent. This extract also demonstrated significant cytotoxicity against pancreatic cancer PANC-1 cells.
- 02 Chlorogenic Acid Methyl Ester (CAME), an identified active compound produced during the fermentation process, displayed potent cytotoxic effects (IC50) on PANC-1 cells at a concentration of 119.1 µg/mL, inducing G0/G1 phase cell cycle arrest and apoptosis.
Transparency
Dusting Analysis
As a soluble ferment filtrate, this ingredient is a liquid component and is not associated with dusting in cosmetic formulations.
The Formula
Formulation
Stability
The fermentation process itself is sensitive to precise pH, temperature, and aeration controls. The resulting filtrate is generally expected to exhibit stability within the typical pH ranges encountered in cosmetic formulations, though specific optimal pH for the final extract's stability is not precisely defined. The ingredient is known to contain weak acids.
Safety
Safety Profile
There is no specific CIR, SCCS, or FDA assessment for the exact combined ingredient 'LACTOBACILLUS/SACCHAROMYCES/STEVIA REBAUDIANA LEAF/STEM EXTRACT FERMENT FILTRATE'. However, its individual ferment components, such as 'Lactobacillus Ferment' and 'Saccharomyces Ferment Filtrate', have been evaluated. The CIR Expert Panel concluded that Lactobacillus Ferment and related ingredients are safe for cosmetic use, with reported concentrations up to 5.6% in face and neck products. Similarly, yeast-derived ingredients like Saccharomyces Ferment Filtrate have been reviewed, with usage up to 0.065% in specific product types. These ingredients function as byproducts of fermentation, not as live microorganisms.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This ferment filtrate is a valuable ingredient, offering comprehensive benefits driven by the enhanced antioxidant profile of fermented stevia and the recognized postbiotic contributions from Lactobacillus and Saccharomyces, making it broadly compatible with various skin types.
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