Science
Mechanism of Action
Lactobacillus Ferment Lysate Filtrate operates by fostering a balanced skin microbiome, essential for cutaneous defense. It strengthens the skin's barrier function through increasing tight junction proteins, leading to a measurable decrease in transepidermal water loss (TEWL), reduced redness, and improved hydration. This ingredient actively modulates the skin's immune responses, promoting the generation of antimicrobial peptides to reinforce natural defenses, while simultaneously inhibiting inflammatory cytokines. It stimulates keratinocyte proliferation and migration, accelerating natural skin renewal processes. Furthermore, it contributes to natural DNA repair mechanisms, aiding recovery from environmental stressors, and suppresses pathogenic bacteria such as Staphylococcus and Streptococcus, preventing various dermatological issues. The ingredient also balances the skin's water-to-oil ratio, regulates microbiota, corrects pH imbalances, and promotes collagen synthesis for enhanced elasticity.
Research
Clinical Evidence
High confidence5%
Key findings
- 01 In a small in-vivo study, a 5% concentration demonstrated notable soothing and anti-irritant properties.
- 02 A product containing this ingredient was evaluated at 100% in Human Repeat Insult Patch Tests (HRIPTs), confirming its non-irritating and non-sensitizing profile.
- 03 A postbiotic cream, formulated with Lactobacillus ferment lysate at a pH of 6.00 ± 0.02, showed clinically significant improvements in the SCORAD index for pediatric atopic dermatitis patients after two months, with reduced disease recurrence observed over four months.
- 04 A lotion containing a fermented lysate blend effectively strengthened the skin barrier and mitigated sensitive skin symptoms within 30 days.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
This ingredient maintains stability up to 60 °C. Exposure to cold temperatures may cause a temporary change in appearance, which can be reversed by warming to 45-50 °C. It remains stable for approximately one year under standard storage conditions, with no known hazardous reactions.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Panel has deemed Lactobacillus Ferment Lysate Filtrate safe for use in cosmetic formulations. While generally non-toxic and well-tolerated, a reported risk of allergic reaction for highly sensitive skin suggests a patch test may be a prudent precaution.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Lactobacillus Ferment Lysate Filtrate is a valuable postbiotic ingredient, scientifically validated to enhance skin barrier function, balance the microbiome, soothe irritation, and support overall skin health and resilience across all skin types.
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