Science
Mechanism of Action
This ingredient functions by reinforcing the skin's natural microbial balance, suppressing harmful bacteria while fostering beneficial ones. It strengthens the skin barrier by increasing tight junction proteins and reducing transepidermal water loss (TEWL), thereby improving hydration. Lactobacillus Ferment Lysate also modulates immune responses, promotes antimicrobial peptide production, and exhibits anti-inflammatory effects by inhibiting cytokine secretion. It stimulates cellular renewal through keratinocyte proliferation and migration, aids in wound repair, and offers antioxidant protection, collectively contributing to improved skin tone, elasticity, and a reduction in visible wrinkles.
Research
Clinical Evidence
Medium confidence5%
Key findings
- 01 A 5% concentration of a related Lactobacillus Ferment Lysate Filtrate demonstrated a 47% reduction in redness in an in-vivo study involving 5 participants.
- 02 Accelerates wound closure and promotes the growth of new skin, suggesting reparative capabilities.
- 03 Significantly decreases transepidermal water loss (TEWL), leading to improved skin hydration.
- 04 Reduces general redness and irritation across various skin conditions.
- 05 Enhances skin tone and elasticity, minimizes the appearance of wrinkles, and boosts cell turnover for a revitalized complexion.
- 06 Clinically demonstrated a significant improvement in pediatric patients with Atopic Dermatitis, indicated by a reduction in SCORAD scores, when incorporated into a postbiotic cream at pH 6.00 ± 0.02.
Transparency
Dusting Analysis
Lactobacillus Ferment Lysate offers a broad spectrum of well-documented benefits, including microbiome support, barrier enhancement, and anti-aging effects, making it a valuable active ingredient rather than a 'dusted' one.
The Formula
Formulation
Stability
Stable for approximately 1 year under normal use and storage conditions. It is soluble in water and can be integrated into both aqueous systems and emulsions. For optimal stability, it should be added during the cooling phase below 70°C (158°F) and before the inclusion of thickeners like xanthan gum or Carbopol Ultrez 10. Preventing enzymatic browning during manufacturing is crucial for long-term product integrity.
Synergies
- May enhance the bioavailability and efficacy of other skincare ingredients through its fermented nature.
Conflicts
- Extremes of temperature
- Strong oxidizers
Safety
Safety Profile
The Expert Panel for Cosmetic Ingredient Safety has deemed Lactobacillus Ferment and its derivatives, including Lysate, safe for cosmetic use within current practices and concentrations up to 10%. It is generally well-tolerated with a low potential for irritation and sensitization, and is non-comedogenic. However, as with any natural ingredient, a patch test is recommended for individuals with known sensitivities.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Lactobacillus Ferment Lysate is a highly valuable, multifunctional ingredient that effectively supports skin health through microbiome balancing, barrier reinforcement, soothing, and anti-aging properties, making it suitable for a wide range of skin types and formulations.
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References
Sources