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LACTOBACILLUS/CUCURBITA PEPO FERMENT EXTRACT.

Valuable CAS - / SKIN CONDITIONING

A probiotic-derived extract, LACTOBACILLUS/CUCURBITA PEPO FERMENT EXTRACT is meticulously crafted by fermenting Cucurbita pepo (pumpkin) with Lactobacillus bacteria. This advanced fermentation significantly amplifies the bioavailability of pumpkin's natural enzymes, vitamins, and antioxidants. It delivers multifaceted benefits from gentle exfoliation to potent anti-aging and anti-inflammatory actions across various skin types.

Summary

Exfoliant Antioxidant Skin-Conditioning Anti-aging Anti-inflammatory Cytoprotective Moisturizing Pore Cleansing Skin Barrier Support Microflora Balancing Oil Regulation Brightening

Science

Mechanism of Action

LACTOBACILLUS/CUCURBITA PEPO FERMENT EXTRACT functions as a gentle enzymatic exfoliant, promoting cellular renewal and effectively shedding dead skin cells without the typical irritation associated with alpha hydroxy acids. The fermentation process enhances the availability of inherent pumpkin enzymes, vitamins A and C, and antioxidants, facilitating deep pore cleansing by breaking down excess oils and impurities. Lactobacillus bacteria actively support a healthy skin microflora and fortify the skin's natural protective barrier. Furthermore, rich pumpkin components, including enzymes, amino acids, and sugars, are critical for maintaining optimal moisture balance. Its antioxidant capabilities provide robust protection against free radical damage. Clinically, it exhibits anti-aging efficacy through the inhibition of collagenase, elastase, and hyaluronidase, alongside stimulating collagen production. Anti-inflammatory effects are evident via its influence on IL-6 and IL-1β cytokine levels, complemented by direct cytoprotective properties. This extract also assists in regulating sebum production and contributes to a visibly brighter, more uniform complexion by reducing hyperpigmentation.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

5%

Key findings

  1. 01 At a 5% concentration, the extract has been observed to facilitate cell renewal with efficacy comparable to 4% glycolic acid, while demonstrating very low irritation. It was found to be hardly more irritating than glycerin and did not irritate sensitive eye tissue.
  2. 02 In concentrations ranging from 125-500 µg/mL, the extract exhibited significant cytoprotective effects on human keratinocytes (HaCaT) and dermal fibroblasts (HDF). It also demonstrated anti-aging properties by inhibiting collagenase, elastase, and hyaluronidase, alongside notable anti-inflammatory action through modulated IL-6 and IL-1β cytokine levels.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Stability

While the fermentation process itself establishes an acidic environment (pH 3.38-3.85) to optimize bacterial growth, the specific optimal pH range for the stability of the final extract within a cosmetic formulation is not explicitly detailed in the available data.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Generally regarded as safe and well-tolerated for topical cosmetic application. Although regulatory bodies recognize related ingredients as safe, individual sensitivities, particularly in those with known pumpkin allergies, are possible. A preliminary patch test is advised before extensive use.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

LACTOBACILLUS/CUCURBITA PEPO FERMENT EXTRACT is a valuable multifunctional ingredient, offering gentle enzymatic exfoliation, robust anti-aging, anti-inflammatory, and comprehensive skin-conditioning benefits across all skin types with a low irritation profile.

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