Science
Mechanism of Action
This ingredient functions as a robust antioxidant, actively combating free radicals and shielding the skin from oxidative stress. Its anti-inflammatory capabilities are evidenced by the inhibition of nitric oxide production, which contributes to reducing redness and irritation. It exerts immunomodulatory effects, suppressing tryptase expression and histamine release, and decreasing IL-31 (a biomarker for histamine-independent pruritus) to deliver anti-itch benefits. Furthermore, it addresses hyperpigmentation by inhibiting tyrosinase activity and melanin synthesis, leading to a more uniform complexion, and supports a balanced skin microbiome, hydration, barrier reinforcement, and cellular renewal.
Research
Clinical Evidence
Medium confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Fermentation processes are known to often enhance the stability of ingredients. Factors such as increased viscosity, larger particle size, and reduced absolute zeta potential contribute to the stability of fermented paste systems.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel concluded that 'Lactobacillus Ferment Ingredients,' a broader category inclusive of this ingredient, are safe as used in cosmetics. A Scientific Literature Review (SLR) Notice to Proceed in February 2025 indicated an ongoing safety assessment with remaining data needs, which was subsequently addressed by a Draft Final Report in September 2025 that concluded safety for a defined group of Lactobacillus ferments. Formulators should be aware that significant skin lightening is classified as a drug effect, and this ingredient should not be employed in a manner intended to cause skin depigmentation.
Your Skin
Skin Compatibility
Our Assessment
Verdict
LACTOBACILLUS/COIX LACRYMA-JOBI MA-YUEN BRAN FERMENT EXTRACT is a valuable ingredient for promoting balanced, soothed, and visibly more even-toned skin through its multi-targeted anti-inflammatory, antioxidant, and brightening actions.
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