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Moumoujus

LABISIA PUMILA EXTRACT.

Valuable CAS - / SKIN CONDITIONING

Labisia Pumila Extract, often known as Kacip Fatimah, is a botanical powerhouse offering multi-faceted benefits for skin. It functions as a potent antioxidant and anti-inflammatory agent, actively combating photoaging and promoting collagen synthesis. This extract contributes to a more resilient, even-toned, and hydrated complexion.

Summary

Antioxidant Soothing Anti-aging UV Protection Collagen Synthesis Support Anti-inflammatory Skin Repair Hydration Even Skin Tone

Science

Mechanism of Action

This extract combats skin aging and damage through multiple pathways. It acts as a powerful antioxidant by neutralizing harmful free radicals, protecting skin from UV-induced damage and maintaining elasticity. Its anti-inflammatory properties inhibit key inflammatory markers like TNF-alpha and COX-2, soothing irritation. Labisia Pumila Extract actively counteracts photoaging by restoring collagen synthesis in fibroblasts, upregulating collagen production, and down-regulating collagen-degrading enzymes (MMP-1, MMP-9). Furthermore, it supports skin repair, aids in reducing hyperpigmentation for an even tone, and provides moisturizing effects. Phytoestrogenic components may also contribute to collagen production and overall anti-aging benefits.

Research

Clinical Evidence

Medium confidence
Effective range 0.005–2%
Optimal

0.05%

Key findings

  1. 01 In vitro, demonstrated 50% free radical scavenging activity, comparable to 156 microM ascorbic acid. It inhibited TNF-alpha and COX-2, restored UVB-decreased collagen synthesis in human fibroblasts, and attenuated MMP-1 and UVB-induced MMP-9 expression in keratinocytes, indicating significant antioxidant and anti-photoaging effects.
  2. 02 Ethanol extracts exhibited ultraviolet protection (SPF range 8.76-49.07) and increased fibroblast collagen synthesis previously disrupted by UVB exposure.
  3. 03 Provided optimal protection against UVB-irradiation to HSF1184 Fibroblast cells and displayed potent anti-inflammatory activity by inhibiting elastase and COX-2.
  4. 04 Aqueous leaf and root extracts, when applied in vivo to rats with burn wounds, demonstrated protective effects and supported wound healing.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Pregnancy
Caution
Sensitization risk Low

A specific extract received FDA approval in 2020 for cosmetic use. The European Food Safety Authority (EFSA) considers it safe as a food supplement for adults (excluding pregnant/lactating women) at doses up to 350 mg/day, advising caution for pregnant/lactating individuals. In vivo dermal toxicity studies indicated a non-observed adverse effect level (NOAEL) up to 1,000 mg/kg, suggesting general safety for skin application at appropriate concentrations. Methanolic extracts showed no cytotoxicity at concentrations up to 100 µg/mL. While water extracts are generally well-tolerated, a petroleum ether extract showed some abnormality in rat tissue, highlighting the importance of extract type.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Labisia Pumila Extract is a valuable ingredient, demonstrating robust antioxidant, anti-inflammatory, and anti-photoaging properties, with promising collagen-supporting and UV-protective effects for diverse skin types.

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