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KUNZEA ERICOIDES LEAF EXTRACT.

Valuable CAS - / ANTIOXIDANT, FRAGRANCE, HAIR CONDITIONING, PERFUMING, SKIN CONDITIONING

Kunzea Ericoides Leaf Extract, derived from the Kanuka tree, is a versatile botanical ingredient rich in beneficial polyphenols. It provides robust antioxidant protection, enhances skin hydration, and promotes cellular regeneration, making it valuable for comprehensive skin health and recovery.

Summary

Antioxidant Skin-conditioning agent Moisturizing Anti-aging UV Protection (adjuvant) Skin Brightening Wound Healing Support

Science

Mechanism of Action

This extract exerts its multifaceted benefits through several distinct pathways. As a potent antioxidant, it mitigates oxidative stress by elevating superoxide dismutase (SOD) activity and efficiently scavenging DPPH free radicals. It bolsters skin moisturization by inhibiting the expression of hyaluronidase-1 (HYAL-1) and HYAL-4, while simultaneously increasing aquaporin 3 (AQP-3) content. For UV protection, the extract suppresses the expression of matrix metalloproteinases-1 (MMP-1) and MMP-14 in UV-induced human keratinocytes (HaCaT). It contributes to skin brightening by decreasing melanin and tyrosinase production, and inhibiting the expressions of microphthalmia-associated transcription factor (MITF), tyrosinase-related protein-1 (TYRP-1), and TYRP-2 in melanoma cells (B16F10). Furthermore, it actively supports wound healing by enhancing the proliferation, migration, and collagen synthesis abilities of human dermal fibroblasts.

Research

Clinical Evidence

Medium confidence
Effective range 0.5–1%
Optimal

0.5-1%

Key findings

  1. 01 Demonstrated the highest cell viability and promoted cell migration significantly in human keratinocytes (HaCaT) and mouse melanoma cells (B16F10). Concentrations exceeding 2.5% and 5% were observed to induce cytotoxicity in these cell lines.
  2. 02 Identified as the optimal concentration for enhancing the proliferation, migration, and collagen synthesis capacity of Human Dermal Fibroblasts (HDFs) in vitro, and was shown to promote wound healing in animal models (rats).

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

The valuable polyphenolic compounds within Kunzea Ericoides Leaf Extract are inherently susceptible to thermal degradation and oxidation. To preserve their integrity and bioactivity, it is recommended to utilize gentle extraction methods, such as maceration, and to avoid exposure to high temperatures during the formulation process.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

No specific safety assessments by regulatory bodies such as CIR, SCCS, or FDA are available for Kunzea Ericoides Leaf Extract. In vitro studies have indicated that higher concentrations (>2.5% and 5%) can induce cytotoxicity, highlighting the importance of adherence to clinically effective, non-cytotoxic concentrations in formulations.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Kunzea Ericoides Leaf Extract is a valuable multi-active ingredient offering precise antioxidant, moisturizing, UV protective, skin brightening, and wound healing benefits, demonstrating optimal efficacy at low, well-defined concentrations.

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