Science
Mechanism of Action
This extract effectively calms skin by inhibiting pro-inflammatory mediators such as PGE2, TNF-α, iNOS, and COX-2, which are often implicated in inflammatory skin conditions. It also promotes a more youthful complexion by enhancing TGF-β signaling, thereby stimulating procollagen 1 production and suppressing collagen-degrading enzymes like MMP-1 and MMP-13. Furthermore, it boosts skin hydration through the upregulation of key markers such as aquaporin-3 (AQP3) and hyaluronan synthase-3 (HAS3), and contributes to skin repair by accelerating fibroblast wound closure. Its robust antioxidant activity stems from a rich content of flavonoids and phenolics.
Research
Clinical Evidence
Medium confidence1%
Key findings
- 01 Topical application of a 1% water extract significantly reduced epidermal and dermal hyperplasia, alongside a decrease in pro-inflammatory cytokines (IL-1β, TNF-α mRNA) in a mouse model mimicking atopic dermatitis.
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
While the Cosmetic Ingredient Review (CIR) has not specifically reviewed this extract, general toxicity research indicates a low risk profile. Oral LD50 values in mice for a water extract were reported at 7.15 ± 0.03 g/kg, and for an ethanolic extract, an LD50 of 6000 mg/kg BW with a NOAEL of 600 mg/kg BW, classifying it as practically non-toxic. EWG Skin Deep rates this ingredient as 'LOW' concern for cancer, allergies & immunotoxicity, and developmental and reproductive toxicity.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Kochia Scoparia Fruit Extract is a valuable ingredient, demonstrating significant anti-inflammatory, anti-aging, and hydrating benefits with a favorable safety profile, making it highly suitable for sensitive, dry, and mature skin types.
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