Science
Mechanism of Action
This ingredient works through a complex blend of bioactive compounds, including flavonoids, phenolic acids, diterpenes, and notably, rosmarinic acid. Rosmarinic acid acts as a potent antioxidant, anti-inflammatory, and antimicrobial agent. Additionally, Acemannan contributes to its anti-inflammatory effects. At a cellular level, Kidachi Aloe Youjyuu activates human fibroblast cells, enhancing collagen production while simultaneously inhibiting Matrix Metalloproteinase-1 (MMP-1), an enzyme responsible for collagen degradation. This multifaceted action provides moisturizing, soothing, and antibacterial properties, aiding in wound healing and overall skin regeneration.
Research
Clinical Evidence
High confidence0.5%
Key findings
- 01 Fermented Aloe arborescens extract (FE) demonstrably enhanced human fibroblast collagen synthesis by up to 170%, showed approximately 95% antioxidant activity, and activated fibroblast cells by up to 175%. FE also effectively inhibited MMP-1 synthesis by 48%. A conventional water extract (WE) at the same concentration provided 140% enhancement in collagen synthesis and 80% antioxidant activity.
- 02 Aloe arborescens oil exhibited a significant 93% antioxidant effect.
- 03 Aloe arborescens extract did not induce DNA damage in human normal skin fibroblasts, indicating low genotoxicity at these concentrations.
Transparency
Dusting Analysis
Kidachi Aloe Youjyuu exhibits clinically significant benefits at concentrations starting from 0.1% for antioxidant effects and up to 0.5% for robust collagen synthesis and fibroblast activation. These concentrations are well within the range for active ingredients, indicating it is not typically included in cosmetic formulations in sub-efficacious 'dusting' amounts.
The Formula
Formulation
Conflicts
- Anthraquinone levels must not exceed 50 ppm for non-medicinal cosmetic applications.
- Potential for irritation in individuals sensitive to fragrances due to small amounts (1-2%) of fragrant essential oil components.
Safety
Safety Profile
The CIR Expert Panel has determined there is insufficient data to definitively support the safety of Aloe Arborescens Leaf Extract in cosmetic products. Primary concerns revolve around potential anthraquinone content; thus, an industry-established limit of 50 ppm or lower for anthraquinones in non-medicinal aloe-derived materials is recommended. Despite CIR's status, EWG Skin Deep rates 'Kidachi Aloe Youjyuu' as 'LOW' for cancer, allergies, immunotoxicity, and developmental and reproductive toxicity, though it also notes 'Missing safety data' and 'Insufficient data to determine safety' by cosmetic industry review. Generally, it presents a low irritancy profile, but fragrance-sensitive individuals should be aware of its minor essential oil components.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Kidachi Aloe Youjyuu is a valuable ingredient, demonstrating potent anti-aging and soothing properties through significant collagen synthesis enhancement and antioxidant activity, suitable for various skin types despite ongoing comprehensive safety data assessment by regulatory bodies regarding its specific extract form.
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References
Sources