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Moumoujus

KHAYA SENEGALENSIS WOOD EXTRACT.

Valuable CAS - / SKIN CONDITIONING

Khaya Senegalensis Wood Extract is a multi-functional botanical ingredient recognized for its comprehensive benefits in skin rejuvenation and protection. It actively promotes skin firmness and elasticity by stimulating collagen XVIII production, while also refining skin texture, minimizing pores, and regulating sebum. Additionally, it offers antioxidant and anti-inflammatory properties, contributing to a smoother, more resilient complexion.

Summary

Antioxidant Skin-Protecting Sebum Control Soothing Firming Elasticity Enhancing Pore Minimizing Skin Smoothing

Science

Mechanism of Action

This extract operates by enhancing the expression of collagen XVIII, particularly within the dermal-epidermal junction, which is crucial for improving skin's structural integrity, leading to increased firmness and elasticity. Its action also extends to reducing pore visibility and contributing to overall smoother skin. The extract demonstrates anti-inflammatory effects by inhibiting heat-induced albumin denaturation and provides antioxidant protection. Furthermore, it helps to regulate sebum production and acts as a protective barrier, supported by its rich content of bioactive compounds such as flavonoids, tannins, saponins, and alkaloids, which may also confer antibacterial benefits.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Demonstrated significant anti-inflammatory activity, inhibiting heat-induced albumin denaturation by 76.01% at 250 µg/mL and 78.02% at 500 µg/mL (in vitro, bark extract).
  2. 02 Increases the expression of collagen XVIII in the skin, leading to enhanced firmness and elasticity (observed with at least 0.5%, and preferably 1.5-8% increase in expression).
  3. 03 Reduces the visibility of skin pores (observed with at least 10%, preferably 20% reduction after 28 days of application) and contributes to smoother skin.
  4. 04 Limits and/or reduces sebum production.
  5. 05 Exhibited antioxidant activity via DPPH reduction, with an IC50 of 27.89±0.07µg/ml (aqueous bark extract).
  6. 06 Accelerated wound closure in rabbits, indicating wound healing activity (stem bark extract).

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

The ingredient is generally considered safe for cosmetic topical application. However, studies on repeated oral administration of high doses (100-200 mg/kg) of aqueous stem bark extracts in rats have indicated potential adverse effects on vital organs such as the kidney and liver, and alterations in serum electrolyte and hematological parameters. These effects were dose-dependent and observed primarily at higher concentrations. Traditional uses suggest that root extracts might induce fewer adverse effects compared to stem bark extracts when consumed orally. This information pertains specifically to high-dose oral intake and is not directly indicative of safety concerns for typical cosmetic topical use.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Khaya Senegalensis Wood Extract is a valuable multi-functional ingredient, offering significant benefits in enhancing skin structure and texture, alongside providing antioxidant, anti-inflammatory, and sebum-regulating effects, with a favorable low irritancy and comedogenicity profile suitable for all skin types.

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