Science
Mechanism of Action
This extract primarily functions by stimulating the synthesis of collagen XVIII, a vital multi-functional collagenous proteoglycan distributed throughout all skin layers. This stimulation leads to improved skin firmness, increased elasticity, and a visibly smoother complexion with reduced pore appearance. Beyond collagen, it provides moisturizing and soothing properties, offers mild antioxidant protection against external aggressions, and exhibits anti-inflammatory effects. It acts as a skin protectant, reinforcing the natural skin barrier against irritants and pathogens, and may also help to regulate sebum production. Its rich phytochemical profile contributes to potential antibacterial activity.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Reduced visibility of skin pores by at least 10%, with some achieving 20%, after 28 days of application (concentration undisclosed in a cream).
- 02 Increased skin elasticity by at least 0.5%, with some demonstrating up to 8%, after 28 days of application (concentration undisclosed in a cream).
- 03 Demonstrated anti-inflammatory effect by inhibiting heat-induced albumin denaturation by 76.01% at 250 µg/ml and 78.02% at 500 µg/ml (in vitro).
- 04 Significantly inhibited hypotonicity-induced haemolysis activity by 91.02% at 250 µg/ml and 93.10% at 500 µg/ml (in vitro).
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Commonly formulated as an active ingredient within a base of glycerin and water, often with maltodextrin.
Safety
Safety Profile
Generally considered safe for topical cosmetic use. Acute oral toxicity studies in rats suggest it may be non-toxic for acute exposure at doses greater than 5000 mg/kg. However, subchronic oral administration in rats (400-2000 mg/kg bw for 28 days) showed significant increases in markers of liver and kidney stress, with histological evidence of cellular damage. These findings relate to high internal doses and are not directly transferable to topical cosmetic application. EWG Skin Deep indicates low concerns for non-reproductive organ system toxicity and biochemical or cellular level changes.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Khaya Senegalensis Bark Extract is a valuable ingredient, demonstrably enhancing skin elasticity and reducing pore visibility, while also offering protective, soothing, and sebum-regulating benefits suitable for a wide range of skin types.
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References
Sources