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Moumoujus

KETOTRAVOPROST.

Avoid CAS 404830-45-1 / HAIR CONDITIONING

Ketotravoprost, a metabolite of the prostaglandin analog Travoprost, is recognized for its direct action in stimulating eyelash growth and thickening. Clinically, it has been shown to enhance lash length and darkness. However, its classification and safety profile within cosmetic applications remain a subject of significant regulatory concern due to its potent pharmacological activity.

Summary

Eyelash growth Eyelash thickening

Science

Mechanism of Action

This compound, also known as 15-Keto Travoprost or 15-Keto Fluprostenol isopropyl ester, is a metabolite of Travoprost. While Travoprost functions as a prodrug and a full agonist for the prostaglandin FP receptor, primarily increasing aqueous humor outflow, Ketotravoprost directly stimulates the growth and thickening of eyelashes. Some data suggests it might also be an inactive metabolite, similar to the metabolism of other prostaglandin analogs.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

0.008%

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Ketotravoprost is highly sensitive to degradation. In its pure form, it requires storage at -20°C for up to 3 years or 4°C for 2 years. When dissolved in solvent, stability is reduced, necessitating storage at -80°C for 6 months or -20°C for 1 month. Similar prostaglandin analogs are known to degrade significantly under extreme pH conditions, oxidation, light, and heat, suggesting these environmental factors should be rigorously avoided. Cold chain shipping is often required.

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) Expert Panel has cited 'insufficient data or information' for Ketotravoprost and related prostaglandin analogs, specifically noting concerns raised by the European Commission Scientific Committee on Consumer Safety (SCCS). The SCCS explicitly stated that prostaglandins and their synthetic analogues are potent pharmacologically active substances and has advised against, or prohibited, their use in eyelash growth-promoting cosmetics, particularly for products applied near the eye. FDA data also reports uses for related prostaglandin analogs in 'other eye makeup preparations' but without sufficient concentration data for a full safety assessment.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Despite demonstrated efficacy in eyelash growth, regulatory bodies like the SCCS have advised against or prohibited its use in cosmetic products due to its potent pharmacological activity and safety concerns, making it unsuitable for cosmetic applications.

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