Science
Mechanism of Action
This ingredient functions by modulating multiple biological pathways within the skin. It exerts anti-inflammatory effects through the downregulation of inflammatory responses, specifically regulating iNOS and NF-κB signaling, and inhibiting the production of nitric oxide (NO) and pro-inflammatory cytokines such as IL-1β, IL-8, and TNF-α. It also possesses antimicrobial properties, effectively suppressing the growth of acne-contributing bacteria, including *Cutibacterium acnes* and *Staphylococcus epidermidis*. Furthermore, Kaempferia Parviflora Rhizome Water demonstrates sebostatic activity by influencing lipogenesis and PPAR-γ expression, which leads to a reduction in triglyceride and lipid accumulation within sebocytes. Its antioxidant capacity helps to mitigate oxidative stress and minimize DNA damage, while also promoting skin rejuvenation through the stimulation of collagen and hyaluronic acid production.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 A standardized Kaempferia parviflora extract (BG100) at 0.2% demonstrated significant anti-aging effects in human 3D skin models and clinical trials. This was evidenced by inhibited senescence, reduced oxidative stress, improved skin structure and function, and enhanced collagen and hyaluronic acid synthesis.
- 02 An ethyl acetate extract of Kaempferia parviflora, formulated at 0.02% in a gel-cream, significantly reduced acne severity in volunteers. The acne severity index decreased by 36.52% after 4 weeks and 52.20% after 6 weeks, accompanied by an 18.19% and 18.54% reduction in erythema, respectively.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
While the active methoxyflavones within Kaempferia parviflora may exhibit low bioavailability, strategic formulation techniques, such as complexation with cyclodextrins, can significantly enhance their water solubility and optimize ingredient delivery.
Safety
Safety Profile
A 0.2% standardized Kaempferia parviflora extract (BG100) was rigorously evaluated and found to be non-irritating and non-sensitizing in both human 3D skin models and clinical trials. An ethyl acetate extract also demonstrated safety, maintaining fibroblast cell viability above 90% at a concentration of 0.1 mg/mL.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Kaempferia Parviflora Rhizome Water is a valuable ingredient, delivering comprehensive benefits for anti-aging and anti-acne concerns, alongside potent antioxidant and anti-inflammatory properties, making it suitable for a wide range of skin types.
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References
Sources